FIGURE 4 from Synergism Between IL21 and Anti-PD-1 Combination Therapy is Underpinned by the Coordinated Reprogramming of the Immune Cellular Network in the Tumor Microenvironment

Le résumé fourni par la source

IL21-anti-HSA/PD-1 mAbs combination therapy alters T-cell function and increases T-cell clonal expansion. A, UMAP showing CD8+ T-cell subsets, including exhausted, cycling, stem-like, effector, and IFN-induced. B, Pseudotime plot of CD8+ T-cell subsets constructed by Monocle3. C, Contour heat map of CD8+ T-cell subsets split by different treatment conditions. D, Bar plots of CD8+ T-cell subsets under different treatment conditions. E, Heat map showing selected DEGs on exhausted CD8+ T cells in different treatment conditions. F, Bar plots showing TCR clonal expansion fractions and average clonal sizes of total CD8+ T cells under different treatment conditions. G, Dot plot showing expression of selected genes associated with the cell cycle on different CD8+ T-cell subsets under different treatment conditions. H, Dot plot showing expression of selected genes associated with glycolysis on different CD8+ T-cell subsets. I, Heat map showing expression of selected DEGs in CD4+ T cells under different treatment conditions. J, TCR clonal expansion fractions and average clonal sizes of CD4+ T cells under different treatment conditions.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.