White matter microstructure characterisation in hippocampal sclerosis and cryptogenic temporal lobe epilepsy

Le résumé fourni par la source

Temporal lobe epilepsy is characterised by heterogeneous aetiology. In this work we focused on hippocampal sclerosis and cryptogenic groups. In order to characterize microstructure white matter alterations underlying the pathology, we performed a regional analysis of the temporal lobe white matter. Our results showed less disruptive microstructural changes in cryptogenic patients. Alterations in Axial Diffusivity and Neurite Density Index in hippocampal sclerosis potentially indicate significant axonal degeneration. Further investigations are needed to ascertain the value of Orientation Dispersion Index as a possible biomarker to predict surgery outcome.

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