Microstructural Deviation in Parkinson’s Disease and Multiple System Atrophy Detected by Spatial Normative Models

Le résumé fourni par la source

By applying spatial normative models based on a population-based cohort, we can quantify the microstructural deviation of white matter in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA). We found that microstructural deviation of the frontal aslant tracts, cerebrospinal tracts, and parts of corpus callosum was more profound in MSA compared to that in PD. Also, the uncinate fasciculi were the common degenerative marker in these two diseases. Moreover, the microstructural deviation of WM tracts may reflect the association with the disease-related daily functional deficit in MSA and the timing of disease onset in PD.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.