Replicability of 1H MR spectroscopic imaging in mild traumatic brain injury

Le résumé fourni par la source

1H-MRS has the potential to provide biomarkers for mild traumatic brain injury (mTBI), a diagnosis in which damage is often imaging-occult, but a lack of replicability and reproducibility studies hampers clinical translation. Here, we tested the replicability of previous MRSI results in mTBI with a different patient cohort. Five out of seven hypotheses were consistent with previous work, with key findings of globally diffuse white matter (WM) injury and limited gray matter injury. However, we report differences in choline and creatine, not N-acetyl-aspartate. Correlations were found between metabolite levels in WM and both symptomatology and neuropsychological testing.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.