R1 Classic and Combined Approaches in Surgical Strategies for Management of Synchronous Colorectal Liver Metastasis

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Background: Liver is the most common target organ of metastasis from colorectal cancer. Surgery is the best treatment for patient of colorectal liver metastasis to achieve long term survival or even complete cure, 5-year survival rate after surgery is about 30 - 50 %. Aim and objectives: to evaluate short-term outcome for 6 months of surgery in management of colorectal cancer liver metastasis by both classic and combined techniques. Subjects and methods: This study was A prospective study included 20 patients in National Cancer Institute & Minya university hospital with synchronous colorectal liver metastasis who undergo surgery by classic and combined techniques, 6 and 14 patients respectively . Result: There was a significant difference found between the groups regarding operative time and blood loss. Thus, operative time and blood loss were significantly higher among combined group compared to staged group. There was no significant difference between the groups regarding demographic data, liver biopsy, type of liver resection, type of colorectal resection, complications, histopathology, recurrence and mortality. Conclusion: sCRLM patients managed with either a staged or simultaneous approach had similar perioperative and short-term outcomes. Both minor and major hepatectomy can be performed safely with low morbidity and mortality as part of either a simultaneous or a staged operative strategy. Although not statistically different, patients who underwent an extended hepatic resection did seem to have a higher perioperative mortality. Keywords: Synchronous Colorectal Liver Metastasis; Classic and Combined Approaches; Surgical Strategies.

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