Microbiological and Clinical Outcomes of Methicillin-Susceptible Staphylococcus aureus Isolated in Lung Transplant Perioperative Donor and Recipient Respiratory Cultures
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Le résumé fourni par la source
Staphylococcus aureus is one of the most common organisms isolated from respiratory secretions in lung transplant donors and recipients perioperatively. Within the first 90 days after lung transplantation, methicillin-susceptible Staphylococcus aureus (MSSA) infections have been associated with increased mortality and acute and chronic rejection. However, it is unclear whether respiratory cultures positive for MSSA at the time of transplantation can lead to clinically significant infection. The aim of this study was to assess the microbiological and clinical outcomes for lung transplant recipients (LTRs) with positive perioperative donor or/and recipient respiratory cultures for MSSA. A retrospective study was conducted evaluating MSSA-positive respiratory cultures at the time of lung transplantation from donors and/or recipients from January 1, 2008, to December 30, 2019. Patients who did not have a bronchoalveolar lavage at 2 weeks after the lung transplant or died within 2 weeks of lung transplant were excluded. The main outcome was MSSA eradication at 2-week bronchoscopy. Recipients were evaluated for MSSA infections at the 12-week period after the transplant. Of the 1,678 individuals who underwent lung transplantation, 218 LTRs had S. aureus isolated in perioperative donor or recipient respiratory cultures, and 29 were subsequently excluded. Of the remaining 189 LTRs, MSSA eradication at the 2-week bronchoscopy was achieved in 186 (98.4%) recipients. During the 12-week follow-up, 15 (7.9%) recipients were diagnosed with MSSA pneumonia; concurrent MSSA bacteremia was noted in one recipient. No anastomotic infection, empyema, or lung abscess related to MSSA was diagnosed during the follow-up period. In LTRs, the rate of MSSA eradication at 2-week post-transplant recipients is high, and it is associated with a low rate of infectious complication within the first 12 weeks after transplant. Most of the recipients received a combination therapy with at least one agent active against MSSA. More studies to evaluate the optimal antimicrobial stewardship policies regarding the regimen and duration of antibiotic therapy for these patients are needed.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Microbiological and Clinical Outcomes of Methicillin-Susceptible <i>Staphylococcus aureus</i> Isolated in Lung Transplant Perioperative Donor and Recipient Respiratory Cultures
- Date Crossref
- 01/01/2023
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University Health Network Ajmera Transplant Centre pays non établi dans la noticeÉtablissement de santé
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University of Toronto pays non établi dans la noticeUniversité ou école supérieure
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King Saud bin Abdulaziz University for Health Sciences King Abdullah International Medical Research Center pays non établi dans la noticeUniversité ou école supérieure
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King Abdulaziz Medical City pays non établi dans la noticeÉtablissement de santé
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King Abdullah International Medical Research Center pays non établi dans la noticeStructure de recherche
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National Guard Health Affairs Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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College of Medicine King Abdullah International Medical Research Center pays non établi dans la noticeUniversité ou école supérieure
Ajmera Transplant Centre — University Health Network, University of Toronto et King Abdullah International Medical Research Center — King Saud bin Abdulaziz University for Health Sciences, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.