3D printing of vascularized hepatic tissues with a high cell density and heterogeneous microenvironment
Rattachement africain : cn, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Three-dimensional bioprinting has emerged as an appealing approach for creating functional tissues; however, a lack of suitable bioinks with high cell density and printability has greatly limited our ability to print functional tissues. We address this limitation by developing a granular cell aggregate-based biphasic (GCAB) bioink based on densely packed cell aggregates. The GCAB bioink exhibited the desired shear-thinning and shear-recovery properties for extrusion bioprinting and hyperelastic behaviors postprinting for modeling the mechanical characteristics of soft biological tissues. The GCAB bioink displayed a high cell density (∼1.7 × 108 cells cm−3) without compromising viability (∼83%). We printed dense hepatic tissue constructs with enhanced vascularization and metabolic functions by preorganization of GCAB bioink with a defined heterogeneous microenvironment. By simultaneously printing the GCAB bioink and an endothelial cell-laden gelatin bioink, we successfully produced functional hepatic tissues with a high cell density and a perfusable vascular network. The design of the generalizable GCAB bioink opens new avenues to create functional tissues for therapeutic applications.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- 3D printing of vascularized hepatic tissues with a high cell density and heterogeneous microenvironment
- Date Crossref
- 20/07/2023
- Éditeur
- IOP Publishing
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tsinghua University Department of Mechanical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Drexel University Department of Mechanical Engineering pays non établi dans la noticeUniversité ou école supérieure
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'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base) pays non établi dans la noticeInstitution
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Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing pays non établi dans la noticeStructure de recherche
Department of Mechanical Engineering — Tsinghua University, Department of Mechanical Engineering — Drexel University et 'Biomanufacturing and Engineering Living Systems' Innovation International Talents Base (111 Base), avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.