Accès ouvert déclaré
2023
article
Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design
Tobias Uhe, Katrin Wasser, Mark Weber-Krüger, Wolf‐Rüdiger Schäbitz, Martin Köhrmann, Johannes Brachmann, Ulrich Laufs, Martin Dichgans, Götz Gelbrich, David Petroff, Christiane Prettin, Dominik Michalski, Andrea Kraft, Thorleif Etgen, Peter D. Schellinger, Hassan Soda, Florian Bethke, Michael Ertl, Bernd Kallmünzer, Martin Grond, Katharina Althaus, Gerhard F. Hamann, Meinhard Mende, Marcus Wagner, Sonja Gröschel, Timo Uphaus, Klaus Gröschel, Rolf Wachter, Marianne Hahn, Frédéric Zuhorn, Leonard Wulff, Jorge Plümer, Lena Kok, Marcel Janz, Alkisti Kitsiou, Julian Gehmeyr, A Dabbagh, Charlotte Huber, Johann Pelz, Katja E. Wartenberg, Oscar Flissakowski, Anna Goschenhofer, Rabia-Basari Hussain, Ina Kim, Stephan Kinze, Christian Kroneberger, M. L. Lingnau, Dennis Lischewski, Florian Muhn, Witold Rogge, M. Schieffer, Anuscheh Setayesh-Roonizi, Paul Sparenberg, Jill Marie Schertel, Peter A. Ringleb, Jan Purrucker, Anne Berberich, Miriam Heyse, Matthias N. Ungerer, Gregor Bauer, Christine Reichardt, Bernhard Ebel, Dragana Milanković-Eberl, Olav Schwarte, Constanze Höcherl, E Asch, Luisa Bojtschuk, Maximilian Frey, Tomáš Dlouhý, Philipp Zickler, Barbara Beier, Lino-Dominic Braadt, Inessa Gabrielyan, Pawel Kermer, Matthias Kaste, Ahmed Anter, Corina Stirbulescu, Nataliia Meleshchenco, Friederike Burgholte, Claus Lüers, Thorsten Steiner, Cierpinski, Lichti Mari-Carmen, Lars Bonowski, Esteban Vajda-Medina, Mareike Probst, Hisham Essa, Benedikt Frank, Benjamin Stolte, Lennart Steffen Milles, Erich Hiermann, Renate Weinhardt Alexandra Rascher, Marius N. Stan, Stefan Kääb, Lars Kellert, Konstantinos Dimitriadis, Anna Kopczak, Bettina Küster, Moritz F. Sinner, Ignaz Steiger, Maria Kaffe, Sebastian Clauß, Daniel Janowitz, Raffael Thaler, Jörg Glahn, Simone Jenniges, Silke Markmann-Boenke, Anne-Sophie Putzer, Michael Schwarze Vera Straeten, Marcus Wiemer, Kosmas Macha, David Haupenthal, Stefanie Balk, Clara-Sophie Kossel, Georg Häusler, Dominik Lehrieder, Peter Cidlinsky, Christian Hametner, Christine Vogl, Thomas H. Fischer, Moritz Till Huttelmaier, Octavian Maniuc Peter Nordbeck, Albrecht von Hardenberg, Martin Jünemann, Tobias Braun, Maxime Viard, Stefan T. Gerner, AlHaj Omar, Sonja Genau, Linus Olbricht, Matthias Wassenberg, Niklas Langguth, Christian Fräbel, Romy Baumgart, Love-Preet Kalra, Norma J. Diel, Frank Hoffmann, Bettine Schönmuth, Anja Giebler, Lorenz Weber, Jan Birringer, Sandra Lichte-Schneider, Daniela Hütwohl, Lars Udo Krause, Martina Petersen, Konstantin Kirchmeier, Л. В. Новикова, Susanne Müller, Sebastian Schellong, Mirko Brudzinski, Ulrich Gerk, Holger Palisch, Frank R. Heinzel, Jana Fett, Avinash Suntha, K Burian, Bettina Schmitz, Anna Gutwinski, Veronika Angermüller, Tameem Alhammoud, Hüsniye Cakiroglu, Ullrich Bach, Darius G. Nabavi, Jens Offermann, Olaf Crome, Boris Dimitrijeski, Carsten Meincke, Burkhard Alber, Robert Müller, Lars‐Peder Pallesen, Volker Pütz, Christian Hartmann, Jörg Berrouschot, Anett Stoll, Janina Keilitz, D. Klunk, R Voigt, Andreas Kastrup, Andreas Schröter, Johannes Schmucker, Waltraud Pfeilschifter, Christoffer Krämer, Milena Wiemers, Micha Simon, Alexander Finke, Christian Weiß, Carsten Hobohm, Katrin Naupold, Karen Bley-Renning, Sabrina De Winter, Sven Poli, Annerose Mengel, Khouloud Poli, Alexandra Gómez Expósito, Joshua Mbroh, Maria Tieck, Michael Rosenkranz, Stefan Boskamp, Nicolas Ritter, Lena Seibel, Christian Schöps, Rebecca Ketzler, Herbert Nägele, Karsten Sydow, Natalia Kurka, Jan Hendrik Schäfer, Daniel Charissé, Katharina Gruber, Konstantin Kohlhase, Franziska Lieschke, Felix Operhalski, Alexander Seiler, Gabor C. Petzold, Felix J. Bode, Sebastian Stösser, Julius N. Meißner, Taraneh Ebrahimi, Julia Nordsiek, Niklas M. Beckonert, Karin Weißenborn, Gerrit M. Große, Hans Worthmann, Ann‐Katrin Hennemann, Svenja Jochmann, J.E.H. Gründahl, Jana Al‐Ayoubi, Johanna Ernst, Oliver Bähr, Herbert Gruber, Sonka Benesch, Thomas Pollinger, Nawar Alachkar, Sonia Busch, S Butz, Mathias Forkmann, Christian Mahnkopf, Thomas Mischke, Steffen Schnupp, Götz Thomalla, Milani Deb‐Chatterji, Bastian Cheng, Mathias Gelderblom, Julia Hoppe, Märit Jensen, Maximilian Schell, Eckhard Schlemm, Lars Marquardt, H. Kazarians, Pia Franziska Rheingans, Kai Hötzer, Dietmar Rose, Tobias Neumann‐Haefelin, Jörg Berthel, Lirim Alijaj, Joachim Krug, Margit Niethammer, Géza-Attila Szöllösi, Marc Obermann, Nicoletta Adochitei, Herwig Strik, Arne Lenz, Frank Steigerwald, Jörg P. Müller, Martin Honermann, Marian Burgstaller, Rainer Kollmar, Maryam Rashid, Ahmad Ganai, Ossendorf, M. Saric, Karl‐Heinz Tischer, Adela Toluli, Frank A. Wollenweber, Laya Rahban, Thais Portugal Silva, Miri Lee, Matthias Julius Grosch, Jens Minnerup, Jan Liman, Martin Nückel, Magdalena Böhm
29Citations signalées — pas une note de qualité
27Institutions déclarées
1Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Atrial fibrillation (AF) is one of the most frequent causes of stroke. Several randomized trials have shown that prolonged monitoring increases the detection of AF, but the effect on reducing recurrent cardioembolism, ie, ischemic stroke and systemic embolism, remains unknown. We aim to evaluate whether a risk-adapted, intensified heart rhythm monitoring with consequent guideline conform treatment, which implies initiation of oral anticoagulation (OAC), leads to a reduction of recurrent cardioembolism. METHODS: Find-AF 2 is a randomized, controlled, open-label parallel multicenter trial with blinded endpoint assessment. 5,200 patients ≥ 60 years of age with symptomatic ischemic stroke within the last 30 days and without known AF will be included at 52 study centers with a specialized stroke unit in Germany. Patients without AF in an additional 24-hour Holter ECG after the qualifying event will be randomized in a 1:1 fashion to either enhanced, prolonged and intensified ECG-monitoring (intervention arm) or standard of care monitoring (control arm). In the intervention arm, patients with a high risk of underlying AF will receive continuous rhythm monitoring using an implantable cardiac monitor (ICM) whereas those without high risk of underlying AF will receive repeated 7-day Holter ECGs. The duration of rhythm monitoring within the control arm is up to the discretion of the participating centers and is allowed for up to 7 days. Patients will be followed for at least 24 months. The primary efficacy endpoint is the time until recurrent ischemic stroke or systemic embolism occur. CONCLUSIONS: The Find-AF 2 trial aims to demonstrate that enhanced, prolonged and intensified rhythm monitoring results in a more effective prevention of recurrent ischemic stroke and systemic embolism compared to usual care.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design
- Date Crossref
- 01/11/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Atrial Fibrillation Management and OutcomesCardiovascular and Diving-Related ComplicationsVenous Thromboembolism Diagnosis and Management