Alcohol consumption, multiple Lugol‐voiding lesions, and field cancerization
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The development of multiple squamous cell carcinomas (SCC) in the upper aerodigestive tract, which includes the oral cavity, pharynx, larynx, and esophagus, is explained by field cancerization and is associated with alcohol consumption and cigarette smoking. We reviewed the association between alcohol consumption, multiple Lugol-voiding lesions, and field cancerization, mainly based on the Japan Esophageal Cohort study. The Japan Esophageal Cohort study is a prospective cohort study that enrolled patients with esophageal SCC after endoscopic resection. Enrolled patients received surveillance by gastrointestinal endoscopy every 6 months and surveillance by an otolaryngologist every 12 months. The Japan Esophageal Cohort study showed that esophageal SCC and head and neck SCC that developed after endoscopic resection for esophageal SCC were associated with genetic polymorphisms related to alcohol metabolism. They were also associated with Lugol-voiding lesions grade in the background esophageal mucosa, the score of the health risk appraisal model for predicting the risk of esophageal SCC, macrocytosis, and score on alcohol use disorders identification test. The standardized incidence ratio of head and neck SCC in patients with esophageal SCC after endoscopic resection was extremely high compared to the general population. Drinking and smoking cessation is strongly recommended to reduce the risk of metachronous esophageal SCC after treatment of esophageal SCC. Risk factors for field cancerization provide opportunities for early diagnosis and minimally invasive treatment. Lifestyle guidance of alcohol consumption and cigarette smoking for esophageal precancerous conditions, which are endoscopically visualized as multiple Lugol-voiding lesions, may play a pivotal role in decreasing the incidence and mortality of esophageal SCC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Alcohol consumption, multiple Lugol‐voiding lesions, and field cancerization
- Date Crossref
- 03/07/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kyoto University pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Public Health Department of Health and Promotion pays non établi dans la noticeOrganisme public
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National Cancer Center Hospital East Department of Gastroenterology and Endoscopy pays non établi dans la noticeÉtablissement de santé
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Kitasato University Department of Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
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Hokkaido University Hospital Division of Endoscopy pays non établi dans la noticeÉtablissement de santé
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Ishikawa Prefectural Central Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Tohoku University Division of Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
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Shizuoka Cancer Center pays non établi dans la noticeOrganisme public
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Osaka National Hospital Department of Surgery pays non établi dans la noticeÉtablissement de santé
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Okayama University pays non établi dans la noticeUniversité ou école supérieure
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Kanagawa Prefectural Hospital Organization pays non établi dans la noticeÉtablissement de santé
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Kanagawa Cancer Center pays non établi dans la noticeÉtablissement de santé
Kyoto University, Department of Health and Promotion — National Institute of Public Health et Department of Gastroenterology and Endoscopy — National Cancer Center Hospital East, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.