Neutralizing antibody levels associated with injectable and aerosolized Ad5-nCoV boosters and BA.2 infection
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Several COVID-19 vaccines are in widespread use in China. Few data exist on comparative immunogenicity of different COVID-19 vaccines given as booster doses. We aimed to assess neutralizing antibody levels raised by injectable and inhaled aerosolized recombinant adenovirus type 5 (Ad5)-vectored COVID-19 vaccine as a heterologous booster after an inactivated COVID-19 vaccine two-dose primary series. METHODS: Using an open-label prospective cohort design, we recruited 136 individuals who had received inactivated vaccine primary series followed by either injectable or inhaled Ad5-vectored vaccine and measured neutralizing antibody titers against ancestral SARS-CoV-2 virus and Omicron BA.1 and BA.5 variants. We also measured neutralizing antibody levels in convalescent sera from 39 patients who recovered from Omicron BA.2 infection. RESULTS: Six months after primary series vaccination, neutralizing immunity against ancestral SARS-CoV-2 was low and neutralizing immunity against Omicron (B.1.1.529) was lower. Boosting with Ad5-vectored vaccines induced a high immune response against ancestral SARS-CoV-2. Neutralizing responses against Omicron BA.5 were ≥ 80% lower than against ancestral SARS-CoV-2 in sera from prime-boost subjects and in convalescent sera from survivors of Omicron BA.2 infection. Inhaled aerosolized Ad5-vectored vaccine was associated with greater neutralizing titers than injectable Ad5-vectored vaccine against ancestral and Omicron SARS-CoV-2 variants. CONCLUSIONS: These findings support the current strategy of heterologous boosting with injectable or inhaled Ad5-vectored SARS-CoV-2 vaccination of individuals primed with inactivated COVID-19 vaccine.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neutralizing antibody levels associated with injectable and aerosolized Ad5-nCoV boosters and BA.2 infection
- Date Crossref
- 03/07/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Chinese Center For Disease Control and Prevention pays non établi dans la noticeOrganisme public
-
National Institute for Viral Disease Control and Prevention pays non établi dans la noticeOrganisme public
-
Yunnan Center for Disease Control And Prevention pays non établi dans la noticeOrganisme public
-
Hubei Provincial Center for Disease Control and Prevention pays non établi dans la noticeOrganisme public
-
National Center for AIDS/STD Control and Prevention pays non établi dans la noticeOrganisme public
-
National Immunization Program pays non établi dans la noticeInstitution
-
National Health Commission (NHC) Key Laboratory of Biosafety pays non établi dans la noticeStructure de recherche
-
Shaanxi Provincial Center for Disease Control and Prevention pays non établi dans la noticeInstitution
-
Yunnan Provincial Center for Disease Control and Prevention pays non établi dans la noticeInstitution
Chinese Center For Disease Control and Prevention, National Institute for Viral Disease Control and Prevention et Yunnan Center for Disease Control And Prevention, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.