Microchimerism as Post-Transplant Marker of a Chronic Rejection Process
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Le résumé fourni par la source
The risk of losing a transplanted organ is high, and non-invasive markers to warn of this phenomenon are still being sought. We investigated the impact of post-transplant microchimerism on the function of the transplanted kidney. The study included 100 kidney transplant recipients, mostly women. All transplanted organs were from opposite-sex deceased donors. Microchimerism was assessed using multiplex PCR. Male DNA was detected in all urine samples from female recipients and in 13/56 blood samples from female kidney recipients. Female DNA was found in 31/44 urine samples from male recipients, but in none of the blood samples. Microchimerism in the urine of female recipients correlated positively with blood urea (Rs = 0.45; p = 5.84 × 10−4) and K+ ions (Rs = 0.29; p = 0.03), while microchimerism in the blood of female recipients also correlated positively with blood urea (Rs = 0. 28; p = 0.04), cystatin C (Rs = 0.31; p = 0.02) and the number of incompatible HLA alleles (Rs = 0.42; p = 0.01). A history of DGF was associated with higher urinary donor DNA concentrations in female recipients.: Post-transplant microchimerism may serve as a potential marker of chronic kidney rejection.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Microchimerism as Post-Transplant Marker of a Chronic Rejection Process
- Date Crossref
- 25/06/2023
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Szczecin Institute of Physical Culture Sciences pays non établi dans la noticeUniversité ou école supérieure
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Pomeranian Medical University Department of General Surgery and Transplantology pays non établi dans la noticeUniversité ou école supérieure
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General and Transplant Surgery Ward with Sub-Departments of Pomeranian Regional Hospital in Szczecin Department of Intensive Care pays non établi dans la noticeÉtablissement de santé
Institute of Physical Culture Sciences — University of Szczecin, Department of General Surgery and Transplantology — Pomeranian Medical University et Department of Intensive Care — General and Transplant Surgery Ward with Sub-Departments of Pomeranian Regional Hospital in Szczecin.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.