Jingfang granules ameliorate inflammation and immune disorders in mice exposed to low temperature and high humidity by restoring the dysregulation of gut microbiota and fecal metabolites
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Le résumé fourni par la source
The dramatic changes in global climate on human health have been extremely severe. The immune disorder caused by low temperature and high humidity (LTHH) have become a severe public health issue. Clinically, Jingfang granule (JF) has the effect of dispelling cold and eliminating dampness, and is widely used in the treatment of cold caused by wind and cold, autoimmune diseases, and COVID-19 with cold-dampness stagnating in the lung pattern. Our study aims to elucidate the effect of JF on LTHH-induced immune disorders in mice as well as the underlying mechanisms. In this study, JF increased the spleen index, improved fecal character, repaired the intestinal barrier and alleviated intestinal inflammatory responses. Most importantly, JF ameliorated immune disorder in LTHH mice, which was manifested primarily by the significant increase in gdT, CD8+ Tcm, and CD8+ Tem cells, as well as the decrease in TH1, TH17, CD4+ Tem1, CD4+ Tem2, immature NK, mature NK cells, and M1-like macrophages. Interestingly, the JF treatment not only regulated the gut microbiota by decreasing the abundance of harmful bacteria, as well as up-regulating the abundance of beneficial bacteria, but also ameliorated the metabolic disorders by reversing the levels of fecal metabolites to normality. The results of the correlation analysis demonstrated a significant association among gut microbiota, fecal metabolites and immune cells. In addition, JF inhibited the TLR4/NF-κB/NLRP3 pathway in LTHH mice. In conclusion, our results suggested that JF alleviated inflammation and immune disorders in LTHH mice by restoring gut microbiota and fecal metabolism.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Jingfang granules ameliorate inflammation and immune disorders in mice exposed to low temperature and high humidity by restoring the dysregulation of gut microbiota and fecal metabolites
- Date Crossref
- 01/09/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tianjin University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Linyi People's Hospital pays non établi dans la noticeÉtablissement de santé
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Luye Pharma (China) pays non établi dans la noticeEntreprise
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Ocean University of China pays non établi dans la noticeUniversité ou école supérieure
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School of Chinese Materia Medica pays non établi dans la noticeUniversité ou école supérieure
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College of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Fei County People's Hospital pays non établi dans la noticeÉtablissement de santé
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State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine pays non établi dans la noticeStructure de recherche
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Linyi Key Laboratory for Immunopharmacology and Immunotoxicology of Natural Medicine pays non établi dans la noticeStructure de recherche
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School of Medicine and Pharmacy Key Laboratory of Marine Drugs pays non établi dans la noticeUniversité ou école supérieure
Tianjin University of Traditional Chinese Medicine, Linyi People's Hospital et Luye Pharma (China), avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.