Effects of a Novel Stereoscopic Flow-Diverting Stent on Intracranial Aneurysm Hemodynamics

Le résumé fourni par la source

Objective: To preliminarily explore the effects of a novel stereoscopic flow-diverting stent on the hemodynamics and pathophysiology of intracranial aneurysm. Methods: Three-dimensional digital subtraction angiography (3D-DSA) and transcranial Doppler ultrasound (TCD) findings and blood examination-related parameters were collected from eligible patients for clinical research. Then a model of aneurysm with its bearing artery was established, based on which a novel stereoscopic flow-diverting stent model was constructed, and hemodynamic data of fluid models with and without novel stereoscopic flow-diverting stent implantation were analyzed. Results: The novel stereoscopic flow-diverting stent could effectively decrease blood flow into the aneurysm and notably reduce blood flow velocity in the aneurysm. The time-averaged wall shear stress (TAWSS) in the aneurysm was distinctly attenuated, and the high shear stress distribution area was also markedly diminished. Conclusion: The novel stereoscopic flow-diverting stent plays an effective isolating role, which is conducive to inducing thrombosis in aneurysm, thus protecting aneurysm vessels. Furthermore, the novel stereoscopic flow-diverting stent can evidently alter the hemodynamic environment in the aneurysm, notably reduce blood flow into the aneurysm, attenuate the mechanical compression of pulsatile blood flow on the vascular wall, and slow down the blood flow velocity in the aneurysm, thus contributing to stabilizing aneurysm. Improving the hemodynamic environment guarantees arterial revascularization and stable thrombosis, thereby effectively controlling the illness.

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