Epidemiological and Clinical Aspects of Neurological Pathologies Associated with HIV infection at Internal Medicine Department of Point “G” University Hospital Center

Résumé fourni par la source

This retrospective study was conducted from 01 January 2011 to 31 December 2016, in purpose to study the link between neurological disorders and HIV infection at internal medicine department of Point “G” Hospital. Were included all HIV patients, seen in outpatient and/or hospitalization, naive or not of antiretroviral treatment; whose HIV was discovered through neurological disorders and/or whose neurological disorders appeared during HIV disease. We collected 344 cases, 169 of which were included, corresponding to a hospital frequency of 49.12%. The patients were mainly married women with a mean age of 41 years. The sex ratio was 0.7 in the women's favour, and the age group (36-45) accounted for 32.5% of cases. Clinically, confusion and headache were the most frequent complaints, at 10.06% and 5.92% respectively. The most frequent neurological manifestations were encephalitis and ischaemic stroke, with 26.56 and 25% respectively. They occurred in less than 6 months in the majority of our patients (55.62% of cases). Topographically, central nervous system damage was the most represented with 56.25% of cases. The occurrence of these neurological manifestations was correlated with the WHO clinical stage. HIV1 was the most represented type with 90.53% of cases. The occurrence of neurological pathologies related to HIV was correlated to the level of detectable viral load and to a low CD4 count. From a therapeutic and evolutionary aspect, the first line scheme represented 60.95% of cases. Despite the efficacy of this multiple anti-retroviral therapy, the prognosis was unfavourable in more than half of our patients (52.66%).

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