Clinical Characteristics and Progression of Geographic Atrophy in a Japanese Population
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
To elucidate the clinical characteristics and progression rate of geographic atrophy (GA) associated with age-related macular degeneration (AMD) in a Japanese population. Retrospective, multicenter, observational study. A total of 173 eyes from 173 patients from 6 university hospitals in Japan were included. Of 173 study eyes, 101 eyes from 101 patients were included in the follow-up group. All patients were Japanese, aged ≥ 50 years and had definite GA associated with AMD in at least 1 eye. The GA area was measured semiautomatically using fundus autofluorescence (FAF) images. In the follow-up group followed for > 6 months with FAF images, the GA progression rate was calculated by 2 methods: mm2 per year and mm per year using the square-root transformation (SQRT) strategy. Simple and multiple linear regression analyses were used to identify the baseline factors associated with the GA progression rate. Clinical characteristics of GA and the GA progression rate. The mean age was 76.8 ± 8.8 years, and 109 (63.0%) were males. Sixty-two (35.8%) patients had bilateral GA. The mean GA area was 3.06 ± 4.00 mm2 (1.44 ± 1.00 mm [SQRT]). Thirty-eight eyes (22.0%) were classified as having pachychoroid GA. Drusen and reticular pseudodrusen were detected in 115 (66.5%) and 73 (42.2%) eyes, respectively. The mean subfoveal choroidal thickness was 194.7 ± 105.5 μm. In the follow-up group (follow-up period: 46.2 ± 28.9 months), the mean GA progression rate was 1.01 ± 1.09 mm2 per year (0.23 ± 0.18 mm/year [SQRT]). In the multivariable analysis, the baseline GA area (SQRT; P = 0.002) and the presence of reticular pseudodrusen (P < 0.001) were significantly associated with a greater GA progression rate (SQRT). Certain clinical characteristics of GA in Asian populations may differ from those in White populations. Asian patients with GA showed male dominance and relatively thicker choroid than White patients. There was a group with GA without drusen but with features of pachychoroid. The GA progression rate in this Asian population was relatively lower than that in White populations. Large GA and reticular pseudodrusen were associated with a greater GA progression rate. Proprietary or commercial disclosure may be found after the references.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Characteristics and Progression of Geographic Atrophy in a Japanese Population
- Date Crossref
- 01/10/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kyoto University Department of Ophthalmology and Visual Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of the Ryukyus pays non établi dans la noticeUniversité ou école supérieure
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Yokohama City University Department of Ophthalmology and Micro-Technology pays non établi dans la noticeUniversité ou école supérieure
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Tokyo Women's Medical University Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Kansai Medical University Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Kagoshima University Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medicine Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
Department of Ophthalmology and Visual Sciences — Kyoto University, University of the Ryukyus et The University of Osaka, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.