Risk factors for mortality and clinical presentation of monkeypox
Rattachement africain : mx, de. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: To describe risk factors for mortality and clinical characteristics in patients with mpox infection at a reference hospital in Mexico. DESIGN: A prospective cohort study was conducted from September to December 2022 at Hospital de Infectología La Raza National Medical Center. METHODS: Study participants were patients that met operational definition of confirmed case of mpox according to WHO criteria. Information was obtained through a case report form that included epidemiological, clinical, and biochemical information. The follow-up period was from initial evaluation for hospitalization until discharge due to clinical improvement or death. Written informed consent was obtained from all participants. RESULTS: Seventy-two patients were included in the analysis, 64 of 72 (88.9%) were people with HIV (PWH). Of the total of patients 71 of 72 (98.6%) were male, with a median age of 32 years old [95% confidence interval (CI), interquartile range (IQR) 27-37]. Coinfection with sexually transmitted infections was reported in 30 of 72 (41.7%). The overall mortality was five of 72 (6.9%). The incidence of mortality rate in PWH was 6.3%. Median days from onset of symptoms to death from any cause during hospitalization was 50 days (95% CI, IQR 38-62). Risk factors for mpox mortality in the bivariate analysis were CD4 + cells count ≤100 cells/μl at the time of assessment RR 20 (95% CI, IQR 6.6-60.2) ( P < 0.001), absence of antiretroviral therapy RR 6.6 (95% CI, IQR 3.6-12.1) ( P = 0.001) and ≥50 skin lesions at presentation RR 6.4 (95% CI, IQR 2.6-15.7) ( P = 0.011). CONCLUSIONS: The clinical presentation between PWH and non-HIV patients was similar in this study, however, reported mortality was associated with advanced-HIV disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Risk factors for mortality and clinical presentation of monkeypox
- Date Crossref
- 08/06/2023
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Mexican Social Security Institute pays non établi dans la noticeOrganisme public
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Centro Médico Nacional La Raza pays non établi dans la noticeÉtablissement de santé
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Center for HIV and Hepatogastroenterology pays non établi dans la noticeÉtablissement de santé
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Hospital de Infectología ‘Dr Daniel Méndez Hernández’ La Raza National Medical Center Infectious Diseases Department pays non établi dans la noticeÉtablissement de santé
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Hospital de Infectología “Dr. Daniel Méndez Hernández” La Raza National Medical Center Infectious Diseases Department pays non établi dans la noticeÉtablissement de santé
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Research Unit pays non établi dans la noticeStructure de recherche
Mexican Social Security Institute, Centro Médico Nacional La Raza et Center for HIV and Hepatogastroenterology, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.