2023
article
A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn’s Disease: A Population-based Study
Hélène Sarter, Guillaume Savoye, Guillemette Marot, Delphine Ley, Dominique Turck, Jean‐Pierre Hugot, Francis Vasseur, Alain Duhamel, Pauline Wils, Fred Princen, Jean‐Frédéric Colombel, Corinne Gower‐Rousseau, Mathurin Fuméry, Raied Al Hameedi, Maria Khatib, SA Turk, E Agoute, J M Andre, M Antonietti, A Aouakli, Anne‐Sophie Armand, Laura Armengol‐Debeir, I Aroichane, Francesca Assi, J P Aubet, É. Auxenfants, A Avram, F Ayafi-Ramelot, K Azzouzi, D Bankovski, B Barbry, N Bardoux, P. Baron, A Baudet, Pauline Bayart, B Bazin, A Bebahani, J P Becqwort, Sara Bellati, V Benet, Habib Benali, Camille Bénard, C Benguigui, E Ben Soussan, A Bental, I. Berkelmans, J. Bernet, K Bernou, C Bernou-Dron, P Bertot, Nathalie Bertiaux-Vandaële, V Bertrand, E Billoud, N Biron, Benjamin Bismuth, M Bleuet, F Blondel, Valérie Blondin, Mariusz Bobula, P Bohon, Vanessa Bondjemah, E Boniface, D Bonkovski, P Bonnière, E Bonvarlet, P Bonvarlet, Arnaud Boruchowicz, R Bostvironnois, M Boualit, Abdelmalek Bouazza, B Bouche, C Boudaillez, C Bourgeaux, Marie Bourgeois, Aurélie Bourguet, A Bourienne, Hamza Boutaleb, Alexis Bouthors, J Branche, George A. Bray, Franck Brazier, P Breban, M Bridenne, Hélène Brihier, Laura Bril, V Brung-Lefebvre, P Bulois, P Burgiere, J Butel, J Y Canva, V. Canva-Delcambre, J P Capron, F Cardot, Sandrine Carette, P. Carpentier, E Cartier, J F Cassar, M Cassagnou, Julie Castex, Pablo Catalá, S Cattan, S Catteau, B Caujolle, G Cayron, C Chandelier, M Chantre, J. Charles, T Charneau, M Chavance-Thelu, Agathe Cheny, Dragoş Chiriţă, A Choteau, J F Claerbout, P Y Clergue, H Coevoet, G Cohen, Stéphanie Coopman, Lucie Cordiez, J Corvisart, Antoine Cortot, F. Couttenier, J F Crinquette, V Crombe, I Dadamessi, Hadjer Daoudi, V Dapvril, T Davion, S Dautreme, J Debas, Sébastien Decoster, N Degrave, F Dehont, C Delatre, Richard Delcenserie, D Delesalle, O Delette, T Delgrange, L Delhoustal, J. S. Delmotte, S Demmane, G Deregnaucourt, P Descombes, J P Desechalliers, P Desmet, Pierre Desreumaux, G Desseaux, Philippe Desurmont, A Devienne, E Devouge, M Devred, A Devroux, A Dewailly, Sébastien Dharancy, A. Di Fiore, D Djedir, R Djedir, Wissam Doleh, M L Dreher-Duwat, Raymond Dubois, Clotilde Duburque, P Ducatillon, Julien Duclay, Bérengère Ducrocq, F Ducrot, P Ducrotté, A Dufilho, C Duhamel, D Dujardin, C Dumant-Forest, Jean Louis Dupas, Floriane Dupont, Y Duranton, A Duriez, N Duveau, K El Achkar, M El Farisi, C. Elie, M C Elie-Legrand, A Elkhaki, M Eoche, E Essmaeel, D Evrard, J P Evrard, A Fatome, B Filoche, L Finet, Marjorie Flahaut, Christian Flamme, D Foissey, P Fournier, M C Foutrein-Comes, P Foutrein, D Fremond, T Frere, Philippe Gallais, C Gamblin, S. Ganga, R Gérard, Guillaume Geslin, Y Gheyssens, N Ghossini, S Ghrib, T Gilbert, Brigitte Gillet, D. Godart, Philippe Godard, J M Godchaux, R Godchaux, G Goegebeur, Odile Goria, F Gottrand, P. E. Gower, B Grandmaison, M Groux, C Guédon, Loïc Guerbeau, Mathilde Gueroult-Dero, J F Guillard, L Guillem, F Guillemot, D Guimberd, B Haddouche, S Hakim, D Hanon, Vincent Hautefeuille, P Heckestweiller, G Hecquet, J P Hedde, H Hellal, P E Henneresse, Benjamin Heyman, M Héraud, S. Hervé, P Hochain, L Houssin-Bailly, Philippe Houcke, B Huguenin, Silviu Iobagiu, S Istanboli, Aleksandar Ivanović, I Iwanicki-Caron, E Janicki, M Jarry, J Jeu, J P Joly, C. Jonas, Anne Jouvenet, F Katherin, A Kerleveo, A Khachfe, A Kiriakos, J Kiriakos, O Klein, Maciej Kohut, R Kornhauser, D Koutsomanis, J E Laberenne, E Lacotte, G Laffineur, Mylène Lagarde, A Lalanne, A Lalieu, P Lannoy, J Lapchin, M Laprand, Dominique Laude, Richard Leblanc, P Lecieux, Stéphane Lecleire, N Leclerc, C Le Couteulx, Jacques Ledent, J Lefèbvre, P Lefiliatre, Charles Le Goffic, Céline Legrand, A Le Grix, Pierre Lelong, B Leluyer, Claire Lemaitre, C Lenaerts, G Lepeut, L Lepileur, A Leplat, E Lepoutre-Dujardin, H Leroi, Maxime Leroy, P. Le Roy, B Lesage, J Lesage, Xavier Lesage, I Lescanne-Darchis, J Lescut, D. Lescut, Baptiste Leurent, Philip T. Levy, M Lhermie, Louise Libier, A Lion, B Lisambert, I. Løge, F Loire, J. Loreau, S Louf, Alexandre Louvet, L Lubret, M.G. Luciani, Damien Lucidarme, J Lugand, O Macaigne, D Maetz, Dominique Maillard, H Mancheron, O Manolache, A B Marks-Brunel, Charline Marre, Raymond Marti, Francisco Martín‐Luján, Guy Martin, E Marzloff, Philippe Mathurin, Jacques Mauillon, V. Maunoury, Jean Maupas, M A Medam Djomo, C Mechior, Ziad Melki, B Mesnard, P Métayer, L Methari, Bénédicte Meurisse, F Meurisse, L. Michaud, X Mirmaran, P Modaine, A Monthe, L Morel, Pierre-Eugène Mortier, Estelle Moulin, O. Mouterde, Nicolas Mozziconaci, J Mudry, Maria Nachury, Eric Nguyen Khac, B Notteghem, V Ollevier, A Ostyn, A Ouraghi, Barriza Oussadou, D Ouvry, B Paillot, Claire Painchart, N Panien-Claudot, Claude Paoletti, A. Papazian, Brodie Parent, Benjamin Pariente, J C Paris, P Patrier, T Paupard, Bart Pauwels, Mathieu Pauwels, Eugénie Penninck, Richard E. Petit, M Piat, S Piotte, C Plane, B Plouvier, Émeline Pollet, P Pommelet, Dana Pop, C Pordes, G Pouchain, P Prades, A Toby Prevost, J C Prevost, Gilles Quartier, Bruno Quesnel, A M Queuniet, J F Quinton, A Rabache, P Rabelle, G Raclot, S Ratajczyk, Delphine Rault, V Razemon, N Reix, Thibaud Renaut-Vantroys, M Revillion, Ghassan Riachi, Christophe Richez, Peter N. Robinson, J Rodriguez, J Roger, J M Roux, A. Rudelli, Ahmed Saber, Peter Schlossberg, David Sefrioui, M Segrestin, D. Séguy, Célik Seminur, Mehmet Sami Serin, A Seryer, F Sevenet, N Shekh, J Silvie, V Simon, Claire Spyckerelle, N Talbodec, Noémie Tavernier, Henriette Tchandeu, A Techy, J Thélu, A Thévenin, Henri Thiebault, John Thomas, J M Thorel, C. Thuillier, Guillaume Tielman, M Tode, J Toisin, J Tonnel, J. Y. Touchais, Philippe Le Toumelin, Y Touze, J L Tranvouez, C Triplet, N Triki, S Uhlen, Emmanuel Vaillant, C Valmage, D Vanco, Nathalie Vandaele-Bertiaux, H. Vandamme, E Vanderbecq, E Vander Eecken, P Vandermolen, P Vandevenne, L Vandeville, Alain Vandewalle, Christina Vandewalle, P Vaneslander, J P Vanhoove, A. Vanrenterghem, Charlotte Vanveuren, Pascale Varlet, I. Vasies, G Verbiese, J Verlynde, Gwénola Vernier-Massouille, P Vermelle, C Verne, P Vezilier-Cocq, Benoît Vigneron, M Vincendet, J Viot, Y M Voiment, Agnès Wacrenier, L Waeghemaecker, J Y Wallez, M Wantiez, F. Wartel, Jan Weber, J L Willocquet, Nathalie Wizla, E Wolschies, OP Zaharia, Sanaa Zaoui, Alberto Zalar, B Zaouri, A Zellweger, C Ziade, Laurent Beaugerie, Matthieu Allez, Frank M. Ruemmele, Antoine Lamer, Michael A. Roy
7Citations signalées — pas une note de qualité
24Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: The identification of patients at high risk of a disabling disease course would be invaluable in guiding initial therapy in Crohn's disease (CD). Our objective was to evaluate a combination of clinical, serological, and genetic factors to predict complicated disease course in pediatric-onset CD. METHODS: Data for pediatric-onset CD patients, diagnosed before 17 years of age between 1988 and 2004 and followed more than 5 years, were extracted from the population-based EPIMAD registry. The main outcome was defined by the occurrence of complicated behavior (stricturing or penetrating) and/or intestinal resection within the 5 years following diagnosis. Lasso logistic regression models were used to build a predictive model based on clinical data at diagnosis, serological data (ASCA, pANCA, anti-OmpC, anti-Cbir1, anti-Fla2, anti-Flax), and 369 candidate single nucleotide polymorphisms. RESULTS: In total, 156 children with an inflammatory (B1) disease at diagnosis were included. Among them, 35% (n = 54) progressed to a complicated behavior or an intestinal resection within the 5 years following diagnosis. The best predictive model (PREDICT-EPIMAD) included the location at diagnosis, pANCA, and 6 single nucleotide polymorphisms. This model showed good discrimination and good calibration, with an area under the curve of 0.80 after correction for optimism bias (sensitivity, 79%, specificity, 74%, positive predictive value, 61%, negative predictive value, 87%). Decision curve analysis confirmed the clinical utility of the model. CONCLUSIONS: A combination of clinical, serotypic, and genotypic variables can predict disease progression in this population-based pediatric-onset CD cohort. Independent validation is needed before it can be used in clinical practice.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn’s Disease: A Population-based Study
- Date Crossref
- 02/06/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Inflammatory Bowel DiseaseAutoimmune and Inflammatory DisordersAutoimmune and Inflammatory Disorders Research