Clinical Characteristics and Outcomes of Vaccinated VS Non-Vaccinated Critically Ill COVID-19 Patients: Retrospective Observation Study
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Le résumé fourni par la source
Objective: We aim to identify the clinical characteristics and outcome of vaccine breakthrough infection in critically ill COVID-19 patients and to compare the clinical course of disease between vaccinated and non-vaccinated patients. Methods: A retrospective review of all adult patients aged ≥ 18 years admitted to the ICU in King Fahd Hospital of the University in Saudi Arabia with positive COVID-19 RT-PCR test between the period of January 1st to August 31st, 2021, were included. The recruited patients were grouped in to “vaccinated and non-vaccinated group” based on their immunization status. The demographic data, co-morbidities, modality of oxygen support, ICU length of stay (ICU LOS) and mortality were collected and analyzed. Results: A total of 167 patients were included. Seventy-two patients (43%) were vaccinated. Cardiovascular diseases were higher among the vaccinated group (33.3% vs 12.6%, p value < 0.001). Requirements of Non-invasive ventilation was significantly lower in vaccinated group compared to non-vaccinated group (73.6% vs 91.6%, p value < 0.011). The rates of intubation were similar between both groups. The total intubation days was longer in non-vaccinated patients compared to vaccinated patients and the median duration of intubation was 8 days vs 2 days, respectively ( p value 0.027). In subgroup analysis, the P/F ratio was significantly higher in patients who received two doses of vaccine compared to single dose ( p value < 0.002). Conclusion: In critically ill COVID-19 patients, the vaccinated group has significantly less need for Non-invasive ventilation, fewer intubation days and less hypoxia compared to non-vaccinated patients. We recommend more policies and public education nationwide and worldwide to encourage vaccination and raise awareness of the general population. Keywords: COVID-19 vaccine, breakthrough infection, intensive care unit, vaccine effectiveness, inflammatory markers
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical Characteristics and Outcomes of Vaccinated VS Non-Vaccinated Critically Ill COVID-19 Patients: Retrospective Observation Study
- Date Crossref
- 01/05/2023
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Imam Abdulrahman Bin Faisal University Department of Internal medicine pays non établi dans la noticeUniversité ou école supérieure
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King Fahad Hospital Hufūf pays non établi dans la noticeÉtablissement de santé
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Dammam Central Hospital pays non établi dans la noticeÉtablissement de santé
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King Khaled Hospital pays non établi dans la noticeÉtablissement de santé
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Ministry of Health pays non établi dans la noticeOrganisme public
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College of Medicine Department of Internal Medicine and Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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King Fahad Hospital Hofuf pays non établi dans la noticeÉtablissement de santé
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Dammam Medical Complex pays non établi dans la noticeInstitution
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King Khalid Hospital- AlKharaj pays non établi dans la noticeÉtablissement de santé
Department of Internal medicine — Imam Abdulrahman Bin Faisal University, King Fahad Hospital Hufūf et Dammam Central Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.