THE USE OF COMMUNITY ENGAGEMENT AND GEOGRAPHIC INFORMATION SYSTEM(GIS) TECHNOLOGY IN MITIGATING THE SPREAD OF COVID-19 WITHIN UNIVERSITY COMMUNITY: UNIVERSITY OF IBADAN MODEL

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tralising antibodies by surrogate virus neutralization test (sVNT) and plaque reduction neutralization test (PRNT).Findings: Among the 1,736 HCWs enrolled in our cohort, 252 HCWs provided pre-and post-vaccination blood samples after each dose of either vaccine.Two doses of BNT162b2 generated levels of neutralizing antibodies (sVNT inhibition = 96.8%,range = 42.8%,98.2%) comparable to those generated by natural infections in the first wave (sVNT inhibition = 84.0%,range = 32.9%,93.8%).Similar levels were achieved with three doses of CoronaVac (sVNT inhibition = 95.3%, range = 64.7%,98.3%) and heterologous vaccination with two doses of CoronaVac followed by a booster dose of BNT162b2 vaccine (sVNT inhibition = 97.0%,range = 85.8%, 97.7%).These antibody levels waned faster after second doses and slower after third doses for both vaccines.Conclusion: The BNT162b2 vaccine and CoronaVac vaccines can generate robust antibody responses comparable to natural infections.Three doses of the CoronaVac vaccine, or a heterologous boost with the BNT162b2 vaccine following two doses of the Coro-naVac vaccine are required to achieve similar levels of neutralising antibodies in vaccinees who received two doses of the BNT162b2 vaccine.

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