Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy
Rattachement africain : ru. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The paradigm of drug delivery via nano- and microcarriers is one of the leading ideas that enable overcoming the limitations of traditional chemotherapy. The trend toward more complex drug carriers capable of multifunctionality is observed in the literature. To date, prospects of stimuli-responsive systems to control the cargo release in the lesion nidus are widely accepted. Both endogenous and exogenous stimuli are employed for this purpose, however, endogenous pH is one of the most common triggers. Unfortunately, scientists face difficulties in the implementation of this idea since a range of biological barriers, drug bioavailability issues, and challenges in the synthesis of carriers with required properties have arisen. Here, we discuss fundamental strategies of pH-responsive drug delivery as well as limits in its application and reveal the main problems, weak sides, and reasons for poor clinical results. Also, we have made an attempt to formulate the profiles of "ideal" drug carrier in the frame of different strategies and considered recently published studies through the lens of these profiles. This approach enables the identification of current trends and promising vectors in the development of pH-responsive drug delivery systems, as well as challenges to be resolved in the next generation of carriers.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy
- Date Crossref
- 05/05/2023
- Éditeur
- MDPI AG
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Saratov State University Science Medical Center pays non établi dans la noticeUniversité ou école supérieure
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Saratov State Medical University Central Research Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Health of the Russian Federation pays non établi dans la noticeOrganisme public
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Sechenov University pays non établi dans la noticeUniversité ou école supérieure
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N. I. Lobachevsky State University of Nizhny Novgorod Institute of Biology and Biomedicine pays non établi dans la noticeUniversité ou école supérieure
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I. M. Sechenov First Moscow State Medical University Institute of Molecular Theranostics pays non établi dans la noticeUniversité ou école supérieure
Science Medical Center — Saratov State University, Central Research Laboratory — Saratov State Medical University et Ministry of Health of the Russian Federation, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.