Malignant Hyperthermia: A Review

Résumé fourni par la source

Disease PrevalenceMalignant hyperthermia is a worldwide disease.The prevalence is challenging to estimate, though likely falls in the range of 1:100,000 anesthetics.8 This difficulty is due to the wide spectrum of MH manifestations, as well as the variable responses to anesthetic agents in susceptible patients.Among patients who have developed an acute MH episode in large case series, half have had exposures to anesthetics before without incident.9,10 Previous exposures to uncomplicated anesthetics, even high numbers, do not eliminate the possibility of an MH reaction: a patient with confirmed MH (by genetic testing) was reported to the MH hotline with an acute episode after 30+ prior general anesthetics.A recent review of 370 patients with RYR1 mutations known to cause MH showed that there was an approximately 40% likelihood of developing MH with a triggering agent in a genetically susceptible individual.11 This makes estimation of the true incidence of MH susceptibility difficult to ascertain, though it remains an uncommon condition.

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