Regeneration and Immortality: Aging of the Jellyfish Turritopsis dohrnii (P12-4.006)

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Objective: Make a description about the regenerative characteristics of the jellyfish Turritopsis dohrnii Investigate how the regenerative processes of the jellyfish allow it to rejuvenate, and if these tissue restoration processes are also found in humans. Background: The jellyfish Turritopsis dohrnii (T. Nutricala) is a cnidarian of the Oceaniidae family that lives in the Mediterranean Sea. It is known as the immortal jellyfish, since through a process of cell development of transdifferentiation it manages to return to a polyp state. The role of regeneration processes and their role in aging have been studied in recent years for their possible applications in humans. Design/Methods: Carry out a narrative review using MeSH terms “Jellyfish”, “Turritopsis dohrnii”, “Aging” in databases such as PubMed, ElSevier, GoogleScholar. Using inclusion criteria “Aging process” and exclusion that correspond. Results: The jellyfish rejuvenation process consists of different stages and mechanisms depending on the state they are in, in addition to having specific differentiation pathways in each one. DNA synthesis, repair processes, telomerase activity and telomere maintenance are found in the literature to be overexpressed to a greater extent in the search stage, compared to the medusa and polyp stages. Transdifferentiation could help understand processes involved in humans in pathologies such as cancer. Conclusions: The regeneration of these jellyfish is mainly by transdifferentiation. This mechanism is related to its ability to rejuvenate, however in humans it is evident in pathologies such as cancer. Current evidence on the effects of regeneration as a result of one of the mechanisms used by jellyfish is scarce, with a large field of research. Disclosure: Miss Velasco has nothing to disclose. Mr. Uribe has nothing to disclose. Mr. Suarez has nothing to disclose. Dr. Villamizar has nothing to disclose. Prof. Vasquez-Velez has nothing to disclose.

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