New polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents

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Aim. Synthesis and study of new polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents.Methods.Organic synthesis, NMR and LC-MS spectroscopy, agar diffusion and broth microdilution methods.Results.A series of anthraquinonehydrazone derivatives are synthesized using the reaction of 2-(morpholinodiazenyl)anthracene-9,10-dione with methylene active compounds in the acetic acid medium.The screening of antimicrobial activity identified the compounds with significant effects against the tested microorganisms with MIC value <186.9 μM.Compounds 5 and 11 with MIC <93.5 μM are effective against yeast fungi whereas compound 5 with MIC <186.9 μM is effective against P.putida, which is multidrug resistant to antibiotics.Conclusions.The obtained hydrazino-anthraquinone derivatives constitute an interesting background for the design of new synthetic agents with antimicrobial activity.

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