Accès ouvert déclaré
2023
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Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Julija Hmeljak, Francisco Sánchez-Vega, Katherine A. Hoadley, Juliann Shih, Chip Stewart, David I. Heiman, Patrick Tarpey, Ludmila Danilova, Esther Drill, Ewan A. Gibb, Reanne Bowlby, Rupa S. Kanchi, Hatice U. Osmanbeyoglu, Yoshitaka Sekido, Jumpei Takeshita, Yulia Newton, Kiley Graim, Manaswi Gupta, Carl M. Gay, Lixia Diao, David L. Gibbs, Vésteinn Thórsson, Lisa Iype, Havish S. Kantheti, David T. Severson, Gloria Ravegnini, Patrice Desmeules, Achim A. Jungbluth, William D. Travis, Sanja Đačić, Lucian R. Chirieac, Françoise Galateau-Sallé, Junya Fujimoto, Aliya N. Husain, Henrique C.S. Silveira, Valerie W. Rusch, Robert C. Rintoul, Harvey I. Pass, Hedy L. Kindler, Marjorie G. Zauderer, David J. Kwiatkowski, Raphael Bueno, Anne S. Tsao, Jenette Creaney, Tara M. Lichtenberg, Kristen Leraas, Jay Bowen, Ina Felau, Jean C. Zenklusen, Rehan Akbani, Andrew D. Cherniack, Michael S. Noble, Jonathan A. Fletcher, A. Gordon Robertson, Ronglai Shen, Hiroyuki Aburatani, B. W. Robinson, Peter J. Campbell, Marc Ladanyi, Adrian Ally, Pavana Anur, Joshua Armenia, J. Todd Auman, Miruna Balasundaram, Saianand Balu, Stephen B. Baylin, Michael J. Becich, Carmen Behrens, Rameen Beroukhim, Craig M. Bielski, Tom Bodenheimer, Denise Brooks, Flavio Mavignier Cárcano, Rebecca Carlsen, André Lopes Carvalho, Dorothy Cheung, Juok Cho, Eric Chuah, Sudha Chudamani, Carrie Cibulskis, Leslie Cope, Daniel Crain, Erin Curley, Assunta De Rienzo, Timothy Defreitas, John A. Demchok, Noreen Dhalla, Rajiv Dhir, Michaël Feldman, Martin L. Ferguson, Shiro Fukuda, Stacey Gabriel, Jianjiong Gao, Johanna Gardner, Julie M. Gastier-Foster, Nils Gehlenborg, Mark Gerken, Gad Getz, Chandra Goparaju, Benjamin Groß, Guangwu Guo, Seiki Hasegawa, David Haussler, D. Neil Hayes, Zachary Heins, Robert A. Holt, Alan P. Hoyle, Carolyn M. Hutter, Steven J.M. Jones, Corbin D. Jones, Jaegil Kim, Nobuyuki Kondo, Thomas Krausz, Ritika Kundra, Kozo Kuribayashi, Phillip H. Lai, Peter W. Laird, Michael S. Lawrence, Darlene Lee, Kristen M. Leraas, Pei Lin, Jia Liu, Wenbin Liu, Eric Minwei Liu, Laxmi Lolla, Adhemar Longatto‐Filho, Yiling Lu, James D. Luketich, Yussanne Ma, Dennis T. Maglinte, David Mallory, Marco A. Marra, Michael Mayo, Jonathan Melamed, Shaowu Meng, Matthew Meyerson, Piotr A. Mieczkowski, Gordon B. Mills, Richard A. Moore, César A. Moran, Scott Morris, Lisle E. Mose, Andrew J. Mungall, Karen Mungall, Takashi Nakano, Rashi Naresh, Angelica Ochoa, Joel S. Parker, Joseph Paulauskis, Arjun Pennathur, Nathan A. Pennell, Robert Penny, Charles M. Perou, Todd Pihl, Nilsa C. Ramirez, Doris M. Rassl, Glen Reid, Rui Manuel Reis, Sheila M. Reynolds, David C. Rice, William G. Richards, Jeffrey Roach, Sara Sadeghi, Gordon Saksena, Chris Sander, Ayuko Sato, Cristovam Scapulatempo‐Neto, Jacqueline E. Schein, Nikolaus Schultz, Steven E. Schumacher, Tanguy Y. Seiwert, Candace Shelton, Troy Shelton, Robert L. Sheridan, Yan Shi, Yuichi Shiraishi, Ilya Shmulevich, Janae V. Simons, Payal Sipahimalani, Tara Skelly, Heidi J. Sofia, Matthew G. Soloway, Paul T. Spellman, Joshua M. Stuart, Qiang Sun, Angela Tam, Donghui Tan, Roy Tarnuzzer, Kenji Tatsuno, Barry S. Taylor, Nina Thiessen, Eric Thompson, Kane Tse, Tohru Tsujimura, Federico Valdivieso, David Van Den Berg, Nico van Zandwijk, Umadevi Veluvolu, Luciano de Souza Viana, Douglas Voet, Yunhu Wan, Jing Wang, Joellen Weaver, John N. Weinstein, Daniel J. Weisenberger, Matthew D. Wilkerson, Lisa Wise, Ignacio I. Wistuba, Tina Wong, Ye Wu, Shogo Yamamoto, Liming Yang, Jiashan Zhang, Hailei Zhang, Hongxin Zhang, Erik Zmuda
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Résumé fourni par la source
Abstract Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity. We also report strong expression of the immune-checkpoint gene VISTA in epithelioid MPM, strikingly higher than in other solid cancers, with implications for the immune response to MPM and for its immunotherapy. Our findings highlight new avenues for further investigation of MPM biology and novel therapeutic options. Significance: Through a comprehensive integrated genomic study of 74 MPMs, we provide a deeper understanding of histology-independent determinants of aggressive behavior, define a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity, and discovered strong expression of the immune-checkpoint gene VISTA in epithelioid MPM. See related commentary by Aggarwal and Albelda, p. 1508. This article is highlighted in the In This Issue feature, p. 1494
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
- Date Crossref
- 03/04/2023
- Éditeur
- American Association for Cancer Research (AACR)
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Sujets associés
Occupational and environmental lung diseasesCancer Research and TreatmentsMedical Imaging and Pathology Studies