Supplementary Figures, Legends and Tables from Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition
Le résumé fourni par la source
Figure S1. Severe DNA replication inhibition in UM-SCC-74a HNSCC line and untransformed primary cells. Figure S2. Efficiency of WEE1 inhibition by AZD1775. Figure S3. Cell cycle progression and �H2AX response in the p53 mutant PCI-15B cells. Figure S4. Inactivation of p53 by expression of E6 protein of HPV16 reproduces AZD1775-dependent phenotypes of shRNA-mediated p53 depletion in UM-SCC-74a cells. Figure S5. Dynamics of �H2AX++ and mitotic cells in p53kd and control UM-SCC-74a recovering from AZD1775. Figure S6. Validation of Sorted microfluidic-assisted Replication Track Analysis (SmaRTA). Table S1: Synergy analysis for AZD1775 and triapine combination in p53kd and control UM-SCC-74a cells. Table S2: Synergy analysis for AZD1775 and CDDP combination in p53kd and control UM-SCC-74a cells as described for Table S1.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Supplementary Figures, Legends and Tables from Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition
- Date Crossref
- 03/04/2023
- Éditeur
- American Association for Cancer Research (AACR)
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.