Supplementary Figure 4 from Systems Analysis of the NCI-60 Cancer Cell Lines by Alignment of Protein Pathway Activation Modules with “-OMIC” Data Fields and Therapeutic Response Signatures

Le résumé fourni par la source

PDF file - 1038K, Systems networks of AKT (A), apoptosis (B), IGF-1R (C) and mTOR (D) pathway activation. Node color: Violet - node representing the Pathway Score; Blue - phosphoproteins (linked to pathway score or to other proteins/genes at the protein level); Yellow - genes (linked to Pathway Score or to other proteins/genes at the mRNA level); Orange - microRNA; Dark green - drug; Light green - metabolite; Gray - other. Node shape: Diamond - Pathway Score node, or phosphoprotein that is used in calculating the Pathway Score; Circle - other nodes. Edge color & label: Brown - relationship inferred based on phosphoprotein level (either with level other phosphoprotein, or with Pathway Score); Gray - relationship inferred based on gene mRNA expression (either with mRNA of other gene, or with Pathway Score); Dark green - phosphoprotein level or gene expression (mRNA) is significantly correlated with drug's response measured as -log(GI50); Light green - phosphoprotein level or gene expression (mRNA) is significantly correlated with metabolite concentration; Red - phosphoprotein level or gene expression (mRNA) is significantly correlated with mutation of other gene. Arrow points from mutation gene to the mRNA gene; Pink - gene expression (mRNA) is significantly correlated with methylation of other gene. Arrow points from methylation gene to the mRNA gene; Dark blue - gene expression (mRNA) is significantly correlated with copy number of other gene. Arrow points from copy number gene to the mRNA gene; Orange - gene expression (mRNA) is significantly correlated with expression of microRNA. Edge line style: Solid - positive correlation; Dashed - negative correlation.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.