Supplementary Materials from Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression

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Supplementary material includes the following: Supplementary Methods: apoptosis assay. Supplementary Table S1: univariate analysis of various risk factors, high ABCE1 or ABCF1 expression on neuroblastoma patient event-free survival. Supplementary Table S2: multivariate analysis of various risk factors, high ABCE1 or ABCF1 expression on neuroblastoma patient event-free survival. Supplementary Figure S1: ChIP-seq tracks showing that the extent of N-MYC binding to the promoter regions of ABCE1 and ABCF1. Supplementary Figure S2: Western blots showing results of all independent experiments of the puromycin incorporation assay. Supplementary Figure S3: Proportion of apoptotic neuroblastoma cells following ABCE1 suppression. Supplementary Figure S4: Inducible ABCE1 suppression reduces growth and migration of MYCN-amplified neuroblastoma cells. Supplementary Figure S5: Analysis of tumor growth in doxycycline-inducible models. Supplementary Figure S6: High ABCE1 expression is associated with elevated N-MYC or c-MYC expression.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.