Supplemental Figures from Aberrant JMJD3 Expression Upregulates Slug to Promote Migration, Invasion, and Stem Cell–Like Behaviors in Hepatocellular Carcinoma

Résumé fourni par la source

This file contains 10 supplemental figures. Supplemental Figure 1. JMJD3 is highly expressed in HCC tissues and cancer cell lines. Supplemental Figure 2. JMJD3 promotes proliferative capacity of HCC cells both in vivo. Supplemental Figure 3. JMJD3 promotes proliferative, EMT, migratory, and invasive capacities of HCC cells. Supplemental Figure. 4 JMJD3 promotes emergence of stem cell-like behavior in HCC cells. Supplemental Figure. 5 JMJD3 promotes emergence of stem cell-like behavior in HCC cells. Supplemental Figure. 6 JMJD3 regulates slug expression need its demethylase activity. Supplemental Figure. 7 JMJD3 regulates slug expression through H3K27 trimethylation Supplemental Figure. 8 JMJD3 regulates slug expression through H3K27 trimethylation Supplemental Figure. 9 Slug is a mediator for JMJD3-induced migration, invasion and in vivo metastasis capacity in HCC cells. Supplemental Figure. 10 Slug is a mediator for JMJD3-induced stemness capacity in HCC cells.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.