Supplementary Figures from Intratumoral HPV16-Specific T Cells Constitute a Type I–Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer

Résumé fourni par la source

Supplementary Figure S1. Handling of oropharyngeal squamous cell carcinoma (OPSCC) material. Supplementary Figure S2. HPV16-positive OPSCC harbor T-cells that specifically recognize the HPV16 oncoproteins E6 and E7. Supplementary Figure S3. High expression of HPV16 antigens by HPV16-positive OPSCC results in induction of HPV16-specific T-cells. Supplementary Figure S4. PHA stimulation of TILs results in differential cytokine production in the various groups of OPSCC patients. Supplementary Figure S5. Mass cytometry analysis reveals importance of CD161 and CD103 expressing intratumoral T-cells in HPV16-positive OPSCC. Supplementary Figure S6. T-helper supernatant neutralizes the type 2 macrophage-like skewing effect of OPSCC tumors. Supplementary Figure S7. Sensitivity and resistance of OPSCC tumor cell lines. Supplementary Figure S8. HPV16-specific CD161+ T-cells are important for controlling the disease.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.