Supplementary Figures S1-S8 from p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis

Résumé fourni par la source

Supplementary Figures S1-S8. Deletion of NEMO and TNF-R1 in NEMOΔhepa and TNF-R1-/- livers (S1); No changes in proliferation despite the up-regulation of cell cycle regulators in p21-deficient NEMOΔhepa livers (S2); Reduced CD45 expression in NEMOΔhepa/p21-/- livers (S3); Increased inflammation in LPS treated animals (S4); TNF-R1 deletion rescues the hypersensitivity of NEMOΔhepa/p21-/- mice against LPS (S5); Development of severe cholestasis is dependent on p21 expression (S6); Enhanced liver injury due to loss of p21 expression in 52 week-old animals (S7); Presence of adenomas in livers of 26 week old animals (S8).