Supplementary Figures CLEAN from Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti–CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo

Résumé fourni par la source

Supplementary Figure 1 shows the anti-mouse CTLA-4 DMAb design. Supplementary Figure 2 shows the efficacy of the recombinant 9D9 antibody in the Sa1N tumor model. Supplementary Figure 3 shows that the mouse anti-mouse CTLA-4 DMAb induces immune memory and protection from tumor re-challenge. Supplementary Figure 4 shows the efficacy of the mouse anti-mouse CTLA-4 DMAb delivered at an earlier time point. Supplementary Figure 5 shows that the anti-mouse CTLA-4 DMAb induces T cell infiltration into tumors. Supplementary Figure 6 shows the efficiency of CD4 and CD8 depletion antibodies.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.