Accès ouvert déclaré2023article
The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study): a UK national observational cohort study
Lewis Hall, Siobhan McKay, James Halle‐Smith, Joshua Soane, Daniel Osei‐Bordom, Lesley Goodburn, Laura Magill, Thomas Pinkney, Ganesh Radhakrishna, Juan W. Valle, Pippa Corrie, Keith Roberts, Terry Lynn Hughes, Rita Perry, Michael A. Walters, Radhika Acharya, Thomas Binnersly, S. J. Brown, Rebecca Everitt, Oscar Hargreaves, Samuel Hodgson, Jacek Parylo, Madeleine Perrett, Daniel J. Smith, Thomas Thorne, Mohamed Abouelazayem, Alison Bradley, Chelise Currow, Richard Fox, Benjamin Giles, Amar Kourdouli, Fahad Mahmood, John Moir, Nicholas Mowbray, Rohan Shotton, Cavitha Vivekananthan, Roxanna Zakeri, Reyad Abbadi, Sian Abbott, Hamza Abdelrahim, Yusria Abukar, Nader Adel, Hussamuddin Adwan, Marriam Ahmed, Shehzad Ahmed, Irfan Ahmed, Ouiam Akotat, Bilal Al‐Sarireh, Amro Alamassi, Gemma Aldous, Bassam Alkari, Ahmed Almonib, Jasim Amin, Muhammad Raheel Anjum, Somaiah Aroori, Ali Arshad, Pallavi Arya, Syed Asfandyar, Usama Aslam, Richard Aspinall, Tejinderjit Athwal, Robert J. Bailey, Nanda Bandlamudi, Sophie Barker, Khalid Bashir, Akshay Bavikatte, Raluca Belchita, Ann Beluso, Katharine Bevan, Imran Bhatti, Amal Boulbadaoui, Tamsin Boyce, Neil Bradley, Corinne Brooks, Chris Brown, Stephanie Burns, Linda Butler, Hannah Byrne, Rubén Canelo, Carlo Ceresa, Georgina Chadwick, Irene Charlesworth, T Chase, Patrick Chen, Raunaq Chhabra, Mei Ying Chin, Zeshan Choudhry, Yooyun Chung, Svetlana Ciocarlan, Jennifer Clark, Danielle Clyde, Maureen Connolly, Kathleen Connors, J. D. Cormack, Meghan Coyle, Andrew Crumley, Emma Davies, Nicola de Liguori-Carino, Filippo Di Franco, K.N. Diong, Matt Doe, Victoria M. Donovan, Jennifer A. Downs, Trish Easton, Tolu Ekong, Utitofon Ekpenyong, Tarek El-housseri, Ahmed Elmaradny, Mohamed Elzubier, E Epanomeritakis, M Erotocritou, Iain Ewing, C Fabelurin, Stephen Falk, Alexia Farrugia, Michael Feretis, Guy Finch, Alasdair Findlay, Simon J. Fisher, Steven Fong, Katherine Fox, Xavier C. C. Fung, Giuseppe Fusai, Laura Gale, Tamara Gall, Giuseppe Garcea, Jaber Gasem, Fanourios Georgiades, J Geraghty, Nader Ghassemi, Mustafa Gherghab, Joanne Giles, Roopinder Gillmore, Leah Gilroy, M Goldsworthy, Alex Grayston, Jordan Green, Roy Gurprashad, Wafaa Hajee-Adam, Shahin Hajibandeh, Clara Hallinan-Rhodes, Adel Hamed, Waseem Hameed, Siddartha Handa, Michael G. Hanna, Mohammad Mahmudul Hassan, Tim Havard, Jennifer M. Hayes, Philip Hayton, Madhu Hebbar, Kerri-Marie Heenan, Christine Higgins, Michael Ho, David Holroyd, Richard Howard, Charlotte Hughes, Nashiz Inayet, Sahra Indayare, Julie Ingmire, Glen Irving, Anita Ivimy, Georgina M. Jackson, Asif Jah, Nigel B. Jamieson, Shameen Jaunoo, Nasir Javed, Arun Jeevagan, Long R. Jiao, Sarah Johnson, Miriam C. Jones, Michael K. Jones, Claire Jones, Dylan Jones, Vicky Jones, Caitlin Jordan, Paul E. Jose, N Joshi, Kunal Joshi, Daniel Kane, Diya Kapila, Syed S. Karim, Muthi Kasimanickam, Mandeep Kaur, Ambareen Kausar, Ben Keatley, Adam Kedzierski, Deepak Kejariwal, Natasha Kelly, Areeb Khan, Aria Khani, Usman Khokar, William Knibbs, Hemant M. Kocher, Ioannis Koumoutsos, Shemin Kovammal, Sarah Kreppel, Tharsika Kuganesan, Yogesh Kumar, Reuben Thomas Kurien, Nikhil Lal, Corina Lavelle, Sophie Laverick, Lauren Laverty, Hemant Laxaman, Alvin Lee, Karen Lloyd-Jones, Pavlos Lykoudis, Aarini Mahalingam, A Majkowska, D Majumdar, Yogeshkumar Malam, K. Mann, Robyn L. Marsh, Harry Martin, J McAleer, Stephen McCain, Hannah McCaughan, Catherine W. McCollum, Kieran McCormack, John McGoran, Morag McLellan, Joseph Meilak, Shyam Menon, Donald Menzies, James Milburn, Andrew Millar, Moeed Minto, Amitabh Mishra, Zain Mitha, Vikramjit Mitra, Sathis Mogan, Badreldin Mohamed, Ghazaleh Mohammadi-Zaniani, Yaser Mohammed, Jaiganesh Mohan, S.C. Morris, Gary R. Morrison, Tamsin Morrison, Matthew Mortimer, Samuel Moulding, Moustafa Mourad, Sujit Mukherjee, Ameer Mustafa, Keval Naik, S. Ali Naqvi, D. Natarajan, Thomas Ngan, Tracey Noakes, Tim Norris, Elizabeth O’Connell, Rebecca O’Kane, David O’Reilly, William O’Rourke, Olaolu Olabintan, Samuel Ololade, Seok Ling Ong, Oluwafemi Osunlusi, Altaf Palejwala, Anna Palepa, Monica Palmer, Constantinos A. Parisinos, Chetan Parmar, Panna Patel, Samir Pathak, Stephen P. Pereira, Stephanos Pericleous, Rosemary Phillips, Lushen Pillay, João Páscoa Pinheiro, Parisa Pirjamali, Yanish Poolovadoo, Mariuca Popa, Sarah Powell‐Brett, Melissa Prior-Ong, David Propper, Leonard Quinn, Khaled Radwan, Alyssa Ralph, Veena Ramachandran, Ganeshan Ramsamy, Hind Rassam, Anjana Ray-Chaudhuri, Srikanth Reddy, Shahriar Reza, Karim Rezk, Paul Rice, Lysia Richmond, Brianda Ripoll, Syed S. H. Rizvi, Sarah Robinson, Natalie Robson, Polly Rogers, Megan Rowley, Thomas Russell, Dana Šafářová, Harkiran Sagoo, Maurice Samake, Sharukh Sami, Kumar Samraj, Panchali Sarmah, Edward Saxton, Bethany Scutt, Chaminda Sellahewa, Gourab Sen, Zara Shaida, Amrita Shandakumar, Nicholas M. Sharer, Syed Shahid Shaukat, Roosey Sheth, Guy Shingler, Amy Shroll, Ajith K. Siriwardena, James Skipworth, Sarah Slater, Conor Smith, Andrew Smith, Opeyemi Sogaolu, Claire E. Stevens, Duncan Stewart, Weronika Stupalkowska, Vikas Sud, Zain Sultan, Luke Summers, Nikhil Suresh, Jonathan Sutton, Wei Jian Tan, Chew Lim Tan, Andrei Tănăse, Lulu Tanno, Luke Taylor, Mark Taylor, Rohan Thakkar, Donna Ojanen Thomas, Emily Thompson, Benjamin Tinsley, Elizabeth Toy, David Tsang, Archil Tsirekidze, Dimitrios Tsironis, Sophie Tucker, T. J. Turner, Varu Udayachandran, Stijn van Laarhoven, Lakshmi Deepa Vandadi, Rebecca Varley, Darmarajah Veeramootoo, Suresh Vasan Venkatachalapathy, Ashwin Verma, M N Vipond, Daniel E. Waite, Amy Ward, Ben Warner, Justin S. Waters, Alexander West, Douglas Whitelaw, Matthew Williams, Rhys Williams, Phoebe Wilson, Danylo Yershov, Alistair A. Young, Muneeb Zafar, Osama Zaman, Melissa Zhao
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Résumé fourni par la source
INTRODUCTION: CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: The treatment of consecutive patients with newly diagnosed PDAC from a pre-COVID-19 pandemic cohort (07/01/2019-03/03/2019) were compared to a cohort diagnosed during the first wave of the UK pandemic ('COVID' cohort, 16/03/2020-10/05/2020), with 12-month follow-up. RESULTS: Among 984 patients (pre-COVID: n = 483, COVID: n = 501), the COVID cohort was less likely to receive staging investigations other than CT scanning (29.5% vs. 37.2%, p = 0.010). Among patients treated with curative intent, there was a reduction in the proportion of patients recommended surgery (54.5% vs. 76.6%, p = 0.001) and increase in the proportion recommended upfront chemotherapy (45.5% vs. 23.4%, p = 0.002). Among patients on a non-curative pathway, fewer patients were recommended (47.4% vs. 57.3%, p = 0.004) or received palliative anti-cancer therapy (20.5% vs. 26.5%, p = 0.045). Ultimately, fewer patients in the COVID cohort underwent surgical resection (6.4% vs. 9.3%, p = 0.036), whilst more patients received no anti-cancer treatment (69.3% vs. 59.2% p = 0.009). Despite these differences, there was no difference in median overall survival between the COVID and pre-COVID cohorts, (3.5 (IQR 2.8-4.1) vs. 4.4 (IQR 3.6-5.2) months, p = 0.093). CONCLUSION: Pathways for patients with PDAC were significantly disrupted during the first wave of the COVID-19 pandemic, with fewer patients receiving standard treatments. However, no significant impact on survival was discerned.
Sujets associés
COVID-19 and healthcare impactsPancreatic and Hepatic Oncology ResearchCOVID-19 Clinical Research Studies