MP08-10 GLOBAL VARIATION IN EARLY RECURRENCE AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR IN THE RESECT STUDY (NCT05154084): THERE IS SIGNIFICANT INTER-SITE VARIATION THAT IS INDEPENDENT OF DIFFERENCES IN TUMOUR FACTORS

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You have accessJournal of UrologyCME1 Apr 2023MP08-10 GLOBAL VARIATION IN EARLY RECURRENCE AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR IN THE RESECT STUDY (NCT05154084): THERE IS SIGNIFICANT INTER-SITE VARIATION THAT IS INDEPENDENT OF DIFFERENCES IN TUMOUR FACTORS Betty Wang, Kevin Gallagher, Nikita Bhatt, Keiran Clement, Eleanor Zimmermann, Sinan Khadhouri, Alexander Kiciak, Meghana Kulkarni, Fortis Gaba, Thines Anbarasan, Alexander Ng, Alexander Light, Aqua Asif, Vinson Chan, Arjun Nathan, Sabrina Rossi, Wendy Geng, David Cooper, Lorna Aucott, Tim O’Brien, Steven MacLennan, Matthew Nielsen, Paramananthan Mariappan, Tim Wollin, BURST/RESECT Global Collaborators, and Veeru Kasivisvanathan Betty WangBetty Wang More articles by this author , Kevin GallagherKevin Gallagher More articles by this author , Nikita BhattNikita Bhatt More articles by this author , Keiran ClementKeiran Clement More articles by this author , Eleanor ZimmermannEleanor Zimmermann More articles by this author , Sinan KhadhouriSinan Khadhouri More articles by this author , Alexander KiciakAlexander Kiciak More articles by this author , Meghana KulkarniMeghana Kulkarni More articles by this author , Fortis GabaFortis Gaba More articles by this author , Thines AnbarasanThines Anbarasan More articles by this author , Alexander NgAlexander Ng More articles by this author , Alexander LightAlexander Light More articles by this author , Aqua AsifAqua Asif More articles by this author , Vinson ChanVinson Chan More articles by this author , Arjun NathanArjun Nathan More articles by this author , Sabrina RossiSabrina Rossi More articles by this author , Wendy GengWendy Geng More articles by this author , David CooperDavid Cooper More articles by this author , Lorna AucottLorna Aucott More articles by this author , Tim O’BrienTim O’Brien More articles by this author , Steven MacLennanSteven MacLennan More articles by this author , Matthew NielsenMatthew Nielsen More articles by this author , Paramananthan MariappanParamananthan Mariappan More articles by this author , Tim WollinTim Wollin More articles by this author , BURST/RESECT Global Collaborators More articles by this author , and Veeru KasivisvanathanVeeru Kasivisvanathan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003223.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To determine if there is significant variation in early recurrence (first check cystoscopy) after transurethral resection of bladder tumor (TURBT) surgery between sites taking part in the RESECT study (NCT05154084) after accounting for tumour characteristics. METHODS: RESECT is an international, multi-centre, observational study. A mixed effects logistic regression model with tumour size, tumour number, tumour grade, tumour stage as fixed effects and site as a random effect was fitted. Cases with first, presumed non-muscle invasive bladder cancer (NMIBC) undergoing TURBT were included. Cases were excluded if first check follow up had not been completed. Sites were excluded if they did not have at least 10 cases with first check follow up. Local and/or national approvals or ethical exemptions were obtained prior to commencing the study at participating sites. RESULTS: After exclusions, 186 sites (UK: 80; Europe: 59; North America: 18; Asia: 17; Africa 7; South America: 3; Oceania: 2), contributing a total 4597 cases (average 25 cases) were included. Median recurrence rate per site was 12% (IQR 0-22) for low grade tumours and 27% (IQR 13-42) for high grade tumours (Figure 1). After controlling for tumour size, number, stage and grade (all significantly and independently associated with early recurrence) (Table 1) there was significant residual variation attributable to site (p<0.0001, intra-class correlation, 0.1). Adjustment for sites improved the regression model from an area under the receiver operating characteristic curve of 0.66 to 0.74. CONCLUSIONS: There is significant variation in the early recurrence rate of NMIBC after TURBT surgery between sites that could not be explained by currently understood tumour features. This may be related to site-specific surgical technique or perioperative practice. Further investigation is warranted to understand the influence of these factors. Source of Funding: Rosetrees Trust, The Urology Foundation, Action Bladder Cancer UK, BJUI International, Karl Storz, Photocure, Medac Pharma © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e97 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Betty Wang More articles by this author Kevin Gallagher More articles by this author Nikita Bhatt More articles by this author Keiran Clement More articles by this author Eleanor Zimmermann More articles by this author Sinan Khadhouri More articles by this author Alexander Kiciak More articles by this author Meghana Kulkarni More articles by this author Fortis Gaba More articles by this author Thines Anbarasan More articles by this author Alexander Ng More articles by this author Alexander Light More articles by this author Aqua Asif More articles by this author Vinson Chan More articles by this author Arjun Nathan More articles by this author Sabrina Rossi More articles by this author Wendy Geng More articles by this author David Cooper More articles by this author Lorna Aucott More articles by this author Tim O’Brien More articles by this author Steven MacLennan More articles by this author Matthew Nielsen More articles by this author Paramananthan Mariappan More articles by this author Tim Wollin More articles by this author BURST/RESECT Global Collaborators More articles by this author Veeru Kasivisvanathan More articles by this author Expand All Advertisement PDF downloadLoading ...

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