Intravenous Injection of Equine Mesenchymal Stem Cells in Dogs with Articular Pain and Lameness: A Feasibility Study
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Le résumé fourni par la source
Osteoarthritis is a frequently occurring joint disorder in veterinary practice. Current treatments are focused on pain and inflammation; however, these are not able to reverse the pathological condition. Mesenchymal stem cells (MSCs) could provide an interesting alternative because of their immunomodulatory properties. The objective of this study was to evaluate the potential of a single intravenous (IV) injection of xenogeneic equine peripheral blood-derived MSCs (epbMSCs) as treatment for articular pain and lameness. Patients with chronic articular pain were injected intravenously with epbMSCs. They were evaluated at three time points (baseline and two follow-ups) by a veterinarian based on an orthopedic joint assessment and an owner canine brief pain inventory scoring. Thirty-five dogs were included in the safety and efficacy evaluation of the study. Results showed that the epbMSC therapy was well tolerated, with no treatment-related adverse events and no increase in articular heat or pain. A significant improvement in lameness, range of motion, joint effusion, pain severity, and interference scores was found 6 weeks post-treatment compared with baseline. This study demonstrates that future research on IV administration of epbMSCs is warranted to further explore its possible beneficial effects in dogs with chronic articular pain and lameness. Clinical Trial gov ID: EC_2018_002.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Intravenous Injection of Equine Mesenchymal Stem Cells in Dogs with Articular Pain and Lameness: A Feasibility Study
- Date Crossref
- 01/06/2023
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ghent University Biometrics Research Center pays non établi dans la noticeUniversité ou école supérieure
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Boehringer Ingelheim (Belgium) pays non établi dans la noticeEntreprise
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Acide Carbonique Pur (Belgium) pays non établi dans la noticeEntreprise
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Boehringer Ingelheim (United States) pays non établi dans la noticeEntreprise
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Faculty of Veterinary Medicine Department of Medical Imaging and Orthopedics pays non établi dans la noticeUniversité ou école supérieure
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Veterinary Center Randstad pays non établi dans la noticeInstitution
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Boehringer Ingelheim Veterinary Medicine Belgium pays non établi dans la noticeInstitution
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Private Referral Practice ‘De Molenkreek’ pays non établi dans la noticeInstitution
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Private Referral Practice 'De Molenkreek' pays non établi dans la noticeInstitution
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Private Referral Practice ‘De Roeck’ pays non établi dans la noticeInstitution
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Private Referral Practice 'De Roeck' pays non établi dans la noticeInstitution
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Veterinary Center Malpertuus pays non établi dans la noticeInstitution
Biometrics Research Center — Ghent University, Boehringer Ingelheim (Belgium) et Acide Carbonique Pur (Belgium), avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.