Clinical and endoscopic characteristics of doxycycline induced esophageal ulcers: retrospective observational study

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Introduction: Doxycycline usage takes an essential place in drug-induced esophageal ulcers.The study aims to investigate the clinical and endoscopic features of doxycycline-induced esophageal ulcers. Materials and Methods:Patients who were treated with doxycycline for several reasons between 2014 and 2021 and who were diagnosed with esophageal ulcer after evaluation of their clinical complaints were included in the study.Patients were evaluated retrospectively in terms of demographic characteristics, clinical complaints, biopsy rate, indications for doxycycline use, endoscopy findings, and ulcer type. Results:The study includes thirty patients.About 70% of the patients were female.Biopsy was performed in 13.3% of the patients.The most common indication for the use of doxycycline was acne vulgaris (53.3%).The most common clinical complaint was dysphagia (43.3%).Esophageal ulcers were most common in the middle esophagus, with 73.3%.In the endoscopic evaluation, the most common ulcer shape was circumscribed form (56%), and most ulcers were single (60%).Conclusion: Esophageal ulcer diagnosis should be considered in patients with complaints such as dysphagia, odynophagia, and chest pain during doxycycline usage.

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