The effect of medical biodegradable magnesium alloy in vivo degradation and bone response in a rat femur model with long-term fixation
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Le résumé fourni par la source
BACKGROUND: It is of great significance to understand the effect of the different corrosion behaviors of magnesium (Mg) alloys manufactured using different casting methods and implanted with different methods on the long-term implantation to expand the application of Mg-based biomedical implants. OBJECTIVE: The effects of four different casting and rolling speeds on the microstructure of an Mg-rare earth (Mg-Re) alloy were analyzed using electron backscatter diffraction (EBSD). METHOD: Four Mg alloys were obtained using vertical two-roll casting (TRC) at 10 m/min, 16 m/min, 24 m/min, and 30 m/min, and their microstructure, corrosion behavior and bone reaction in vivo were studied. RESULTS: The corrosion resistance of the alloy increases with an increase in casting speed and finer grain size of the cast-rolled parts. The Mg-Re alloys with TRC-10 m/min and TRC-30 m/min were selected for animal experiments. The two Mg alloys were made into metal rods and inserted into the rat femur to simulate the effect of Mg-Re on femoral healing under an injury condition. The rods were implanted for a long time to judge the effects of the Mg-Re alloy on the body. The TRC-30 m/min implants obtained highly mature new bone tissue in the case of bone injury. CONCLUSION: The in vivo experiments showed that the corrosion resistance of the TRC-30 m/min implant was better than that of the TRC-10 m/min implant. After 32 weeks of implantation, there were no pathological changes in the liver, heart, or kidney of rats in the TRC-30 m/min group, and the cell structure was normal.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The effect of medical biodegradable magnesium alloy in vivo degradation and bone response in a rat femur model with long-term fixation
- Date Crossref
- 01/09/2023
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Saitama Institute of Technology pays non établi dans la noticeUniversité ou école supérieure
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University of Science and Technology Liaoning pays non établi dans la noticeUniversité ou école supérieure
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Ningbo Institute of Industrial Technology pays non établi dans la noticeStructure de recherche
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Graduate School of Engineering Department of Life Science and Green Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Ningbo Haizhi Institute of Materials Industry Innovation pays non établi dans la noticeStructure de recherche
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School of Materials and Metallurgy pays non établi dans la noticeUniversité ou école supérieure
Saitama Institute of Technology, University of Science and Technology Liaoning et Ningbo Institute of Industrial Technology, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.