Monitoring the clinical practice of palliative sedation (PALSED) in patients with advanced cancer: an international, multicentre, non-experimental prospective observational study protocol
Rattachement africain : nl, es, be, de, it, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Palliative sedation involves the intentional lowering of consciousness at the end of life. It can be initiated to relieve a patient's burden caused by refractory symptoms at the end of life. The impact of palliative sedation needs to be clinically monitored to adjust the proper dose and regimen of sedative medication to ensure that patients are at ease and comfortable at the end of their lives. Although there is consensus among health care professionals and within guidelines that efficacy of palliative sedation needs to be closely monitored, there is no agreement about how, when, and by whom, this monitoring should be performed. The aim of this study is to evaluate the effects of palliative sedation by measuring the discomfort levels and sedation/agitation levels of the patients at regular timepoints. In addition, the clinical trajectories of those patients receiving palliative sedation will be monitored and recorded. METHODS: The study is an international prospective non-experimental observational multicentre study. Patients are recruited from in-patient palliative care settings in Belgium, Germany, Italy, Spain and the Netherlands. Adult patients with advanced cancer are monitored by using proxy observations of discomfort (DS-DAT) and depth of sedation/agitation levels (RASS-PAL) during palliative sedation. After the palliative sedation period, the care for the specific participant case is evaluated by one of the attending health care professionals and one relative via a questionnaire. DISCUSSION: This study will be the first international prospective multicenter study evaluating the clinical practice of palliative sedation including observations of discomfort levels and levels of sedation. It will provide valuable information about the practice of palliative sedation in European countries in terminally ill cancer patients. Results from this study will facilitate the formulation of recommendations for clinical practice on how to improve monitoring and comfort in patients receiving palliative sedation. TRIAL REGISTRATION: This study is registered at Clinicaltrials.gov since January 22, 2021, registration number: NCT04719702.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Monitoring the clinical practice of palliative sedation (PALSED) in patients with advanced cancer: an international, multicentre, non-experimental prospective observational study protocol
- Date Crossref
- 28/01/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
-
Radboud University Medical Center Department of Anaesthesiology pays non établi dans la noticeOrganisme public
-
Navarre Institute of Health Research pays non établi dans la noticeUniversité ou école supérieure
-
Clinica Universidad de Navarra Departement of Palliative Medicine pays non établi dans la noticeÉtablissement de santé
-
Universidad de Navarra pays non établi dans la noticeUniversité ou école supérieure
-
KU Leuven pays non établi dans la noticeUniversité ou école supérieure
-
University Hospital Bonn pays non établi dans la noticeÉtablissement de santé
-
La Maddalena pays non établi dans la noticeÉtablissement de santé
-
Lancaster University pays non établi dans la noticeUniversité ou école supérieure
-
Radboud University Medical Centre Department of Primary and Community Care pays non établi dans la noticeUniversité ou école supérieure
-
Instituto de Investigación Sanitaria de Navarra IdISNA pays non établi dans la noticeStructure de recherche
-
Institute for Culture and Society-ATLANTES pays non établi dans la noticeStructure de recherche
Radboud University Nijmegen, Department of Anaesthesiology — Radboud University Medical Center et Navarre Institute of Health Research, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.