Cognitive rehabilitation for improving cognitive functions and reducing the severity of depressive symptoms in adult patients with Major Depressive Disorder: a systematic review and meta-analysis of randomized controlled clinical trials
Rattachement africain : ir. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Introduction Nearly 40% of patients with Major Depressive Disorder (MDD) have been found to experience cognitive impairment in at least one domain. Cognitive impairment associated with MDD is disproportionately represented in patients that have not fully returned to psychosocial functioning. As awareness regarding cognitive dysfunction in MDD patients grows, so does the interest in developing newer treatments that specifically address these deficits. Method In the present study, we conduct a systematic review of controlled randomized clinical trials that used cognitive training and remediation interventions for improving cognitive functions and reducing symptom severity in adult patients with MDD. We selected studies published before March 2022 using search databases including PubMed, ScienceDirect, Scopus, and Google scholar. For conducting the meta-analysis, standard differences in means with the random effect model and with a 95% confidence interval of change in outcome measures from baseline to post-intervention between the cognitive rehabilitation and the control groups were calculated. Results The database search resulted in identifying 756 studies of interest, which ultimately 15 studies with 410 participants in the cognitive rehabilitation group and 339 participants in the control group were included. The meta-analysis of the data extracted from these studies, shows a moderate and significant effect on the executive function (d = 0.59 (95% CI, 0.25 to 0.93) p -value = 0.001, I 2 = 15.2%), verbal learning (d = 0.45 (95% CI, 0.12 to 0.78) p -value = 0.007, I 2 = 0.00%), and working memory (d = 0.41 (95% CI, 0.18 to 0.64) p -value < 0.001, I 2 = 33%) of MDD patients. Although, there were no significant difference between intervention and control group in attention (d = 0.32 (95% CI, -0.01 to 0.66) p -value = 0.058, I 2 = 0.00%) or depressive symptoms. Conclusion This systematic review and meta-analysis indicate that cognitive rehabilitation is an effective intervention for the executive function, verbal learning, and working memory of MDD patients. Due to the importance of these neuropsychological deficits in day-to-day life and the core symptoms of MDD, cognitive rehabilitation should be considered an important part of treating MDD. Further research in this area and concentrated on these particular deficits is warranted.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cognitive rehabilitation for improving cognitive functions and reducing the severity of depressive symptoms in adult patients with Major Depressive Disorder: a systematic review and meta-analysis of randomized controlled clinical trials
- Date Crossref
- 27/01/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Social Welfare and Rehabilitation Sciences Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Iran University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Tehran Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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Kharazmi University pays non établi dans la noticeUniversité ou école supérieure
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Institute for Cognitive Science Studies pays non établi dans la noticeStructure de recherche
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School of Allied Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Kharrazmi University Department of Clinical Psychology pays non établi dans la noticeUniversité ou école supérieure
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Institute for Cognitive Sciences Studies pays non établi dans la noticeStructure de recherche
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Brain and Cognition Clinic pays non établi dans la noticeÉtablissement de santé
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School of Medicine Mental Health Research Center pays non établi dans la noticeUniversité ou école supérieure
Department of Psychiatry — University of Social Welfare and Rehabilitation Sciences, Iran University of Medical Sciences et Department of Psychology — University of Tehran, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.