Abstract C118: Differences in cervical cancer incidence and screening rates in Guam

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Abstract Background: Guam population is 85.9% Asian-Pacific Islander. The cervical cancer incidence and mortality rates are higher on Guam than in the US (9.8 vs 7.4 and 7.6 vs 2.3 respectively; per 100,000 women, aged adjusted, based on 2013-2017 cases and deaths). The purpose of this study was to explore the differences in cervical cancer incidence and screening among ethnic groups on Guam. Methods: This study included 171 in situ and 146 malignant cases reported to Guam Cancer Registry from 1998-2017 (N = 317) with known age and ethnicity. The negative binomial regressions were used to compare rates adjusted for age among CHamoru (N = 189), Filipino (N = 69), and Micronesian women (N = 63) by behavior. The 2012-2018 Behavioral Risk Factor Surveillance System (BRFSS) data was utilized to compare the Pap testing screening behaviors among three major ethnic groups on Guam; including 1077 Filipino, 1598 CHamoru, and 257 Micronesians women. The primary outcome was self-reported Pap testing within 3 years (yes/no). The multivariable logistic regression model was used to assess the differences in Pap testing by ethnicity after adjusting for covariates. Results: The incidence rate ratio (IRR) of invasive cases was significantly higher for CHamoru and Micronesian women when compared to Filipino women (IRR=2.04, 95% CI: 1.19-3.49, and IRR=4.89, 95% CI: 2.69-8.86 respectively). For in-situ cases, only CHamoru women had significantly higher rates than Filipino women (IRR=2.17, 95% CI=1.23-3.86). Pap testing prevalence differed significantly between ethnic groups even after adjusting for age, income level, education level and marital status (p<0.001). Compared to Filipino women, CHamoru women were more likely to receive Pap test (OR=1.56, 95% CI: 1.30-1.87), and Micronesian women were less likely to be screened (OR=0.70, 95% CI: 0.52-0.94). Conclusions: There were significant differences in cervical cancer incidence and screening rates. Micronesian women had the highest invasive incidence rate but the lowest screening rates. There is a need for more outreach effort on Guam. Citation Format: Louis Dulana, Rodney Teria, Renata Bordallo, Lynne Wilkens, Grazyna Badowski. Differences in cervical cancer incidence and screening rates in Guam [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C118.

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