Humoral Response after Two Doses of BNT162b2 mRNA Vaccine Has a Role in Predicting Response after Three Doses That Is Related to Plasma HIV Viremia and Nadir CD4+ Cell Count in HIV-Positive Patients
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Le résumé fourni par la source
We investigated the spike IgG levels of HIV+ patients on antiretroviral therapy six months after they received their second dose (T2) and six months after the third dose (T3) of the BNT162b2 mRNA vaccine, as well as the influence of different levels of plasma HIV viremia of overall CD4+ cell count and nadir value on the humoral time course. One hundred eighty-four patients were enrolled. The median age was 55 years, the median CD4+ cell count was 639 cells/mm3 and the median nadir value was 258 cells/mm3. On the basis of all tests performed during the study period, persistently undetectable plasma HIV RNA (PUD) was found in 66 patients, low-level viremia (LLV) in 57 and ongoing viremia (OV) in 61. Serum levels of IgG antibodies against a trimeric S-protein antigen were tested with DiaSorin Liaison SARS-CoV-2 TrimericS IgG and the response was classified as optimal (>75th percentile), intermediate (50th−25th percentile) and low (<25th percentile). The frequencies of the three different patterns of plasma HIV viremia (PUD, LLV and OV) were comparable in patients with low, intermediate and optimal IgG response evaluated at T2, with no difference in overall CD4+ cell count or nadir count. At T3, 92.9% of patients achieved an optimal response: T2 response proved to be the most important factor in predicting T3 optimal response in patients with LLV and OV.A nadir value ≤ 330 cells/mm3 had 100% sensitivity in predicting a non-optimal response. In conclusion, we demonstrated the persistence of anti-spike IgG, with high serum levels occurring in most patients six months after the third dose of the BNT162b2 mRNA vaccine and a predictive role of humoral response at T2 in subjects with detectable plasma HIV viremia. Immunological alterations related to past immunodeficiency may persist despite immune reconstitution, and the nadir value could be a useful tool for elaborating personalized vaccine schedules.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Humoral Response after Two Doses of BNT162b2 mRNA Vaccine Has a Role in Predicting Response after Three Doses That Is Related to Plasma HIV Viremia and Nadir CD4+ Cell Count in HIV-Positive Patients
- Date Crossref
- 30/12/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Padua pays non établi dans la noticeUniversité ou école supérieure
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Ca' Foncello Hospital pays non établi dans la noticeÉtablissement de santé
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University of Rome Tor Vergata pays non établi dans la noticeUniversité ou école supérieure
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Ospedale dell' Angelo pays non établi dans la noticeÉtablissement de santé
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University of Padova Department of Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ca’ Foncello University Hospital Department of Specialist and Laboratory Medicine pays non établi dans la noticeUniversité ou école supérieure
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Hospital Health Management Area pays non établi dans la noticeÉtablissement de santé
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Tor Vergata University and Hospital Department of System Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Clinical Medicine Unit of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Treviso Hospital Infectious Diseases Unit pays non établi dans la noticeÉtablissement de santé
University of Padua, Ca' Foncello Hospital et University of Rome Tor Vergata, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.