Effect of Caffeine on Colonic Manometry in Children
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Le résumé fourni par la source
OBJECTIVES: Coffee and caffeinated products have been widely consumed for many centuries. Previous adult studies have suggested that both coffee and decaffeinated beverages induce colonic motility. However, no study has been conducted in pediatrics, and the role of caffeine alone in pediatric colonic motility needs to be explored. METHODS: A prospective study of pediatric patients undergoing standard colonic motility testing that were able to consume caffeinated coffee, decaffeinated coffee, and caffeine tablet during colonic manometry. Patients who had a gastrocolonic reflex and high amplitude propagated contractions (HAPCs) in response to intraluminal administration of bisacodyl in the colon were included in the final analyses. RESULTS: Thirty-eight patients were recruited, 22 of which were excluded, 11 due to abnormal studies (no HAPC seen in response to intraluminal response to bisacodyl), and 11 due to inability to consume all study agents or complete the study. Sixteen patients met criteria for final analyses. Intracolonic bisacodyl produced a larger area under the curve (AUC) compared to all other agents. Caffeinated coffee resulted in a higher AUC, motility index (MI), and time to HAPC compared with decaffeinated coffee ( P < 0.05). There was no significant difference between caffeinated coffee and caffeine tablet, or caffeine tablet and decaffeinated coffee. CONCLUSIONS: Caffeine is indeed a colonic stimulant; however, other components of caffeinated and non-caffeinated beverages likely induce colonic response and require further evaluation for possible use as a colonic stimulant.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effect of Caffeine on Colonic Manometry in Children
- Date Crossref
- 29/09/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Orlando Health pays non établi dans la noticeÉtablissement de santé
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Arnold Palmer Hospital for Children pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic in Arizona Division of Pediatric Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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Palm Beach Neurology pays non établi dans la noticeStructure de recherche
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University of Florida pays non établi dans la noticeUniversité ou école supérieure
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Division of Pediatric Gastroenterology and Hepatology Mayo Clinic Rochester MN pays non établi dans la noticeÉtablissement de santé
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Palm Beach Digestive Associates Delray Beach FL pays non établi dans la noticeInstitution
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UCF College of Medicine Orlando FL pays non établi dans la noticeUniversité ou école supérieure
Orlando Health, Arnold Palmer Hospital for Children et Division of Pediatric Gastroenterology and Hepatology — Mayo Clinic in Arizona, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.