Radiotherapy in the management for intracranial meningioma: a systematic review and network meta-analysis

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the PPIX concentration in these cells.The aim of this study was to investigate whether adding Ko-143 may influence effect of PDT.Methods: To evaluate this U87 Glioma cell lines were incubated with 5-ALA (100 μg/ml) and with 5-ALA and Ko-143 (1μM).Cells were irradiated with a laser for 1 hour, with an intensity of 0.1 and 0.2 Watt.WST-1 viability test was performed 24 hours after Laser irradiation to assess cell viability.Control groups included cell lines incubated without 5-ALA, incubated only with Ko-143, or not irradiated with laser.Results: Cell viability after PDT of cells incubated with 5-ALA was significantly lower than the control groups (P<0.05).Additional incubation with Ko-143 lead to a significant enhanced efficacy of DPT on cell viability in comparison with 5-ALA alone (P<0.05).Incubation with Ko-143 alone did not have any effect.Conclusion: Adding Ko-143 to 5-ALA leads to higher effect of PDT, with significantly higher rate of cell death.Further experiments with other cell lines, and viability essays should be performed in order to further evaluate these results.

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