ANTI-INFLAMATORY AND ANTI-LIPID PEROXODATION POTENTIALS OF SALVIA CHUDAEI BATT. et TRAB. AND LAVANDULA ANTINEAE MAIRE: ENDEMIC PLANTS FROM ALGERIAN SAHARA

Résumé fourni par la source

The present study was undertaken to investigate the anti-inflammatory and anti-lipid peroxidation activities of two endemic plants of the central Sahara; Salvia chudaei Batt. et Trab and Lavandula antineae Maire (Lamiaceae), as well as their chemical composition of hydromethanolic extracts. In the test of carrageenan-induced oedema in mice, L. antineae extract, at the dose of 200 mg/kg, revealed good anti-inflammatory activity (P˂0.05) showing 80.74% reduction in the paw thickness comparable to that produced by the standard drug aspirin an83.44% at 4h, while S. chudaei extract was found to have moderate activity (50.74%). When the plant extracts were applied topically at a dosage of 1 and 2 mg per ear, the reduction of ear oedema inflammation was very remarkable compared to the mice of the control group. The plant extracts also showed anti-lipid peroxidation activity with no significant difference compared to ascorbic acid (77.63 ± 1.58%). In addition, the chemical characterization of two extracts by HPLC-DAD revealed the presence of various phenolic acids and flavonoids. These findings showed that Lavandula antineae and Salvia chudaei displays remarkable anti-inflammatory and anti-lipid peroxidation activities and hence can be potential natural sources in health and medicine.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.