What matters most to patients with multiple myeloma? A Pan-European patient preference study
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Le résumé fourni par la source
Introduction Given the rapid increase in novel treatments for patients with multiple myeloma (MM), this patient preference study aimed to establish which treatment attributes matter most to MM patients and evaluate discrete choice experiment (DCE) and swing weighting (SW) as two elicitation methods for quantifying patients’ preferences. Methods A survey incorporating DCE and SW was disseminated among European MM patients. The survey included attributes and levels informed by a previous qualitative study with 24 MM patients. Latent class and mixed logit models were used to estimate the DCE attribute weights and descriptive analyses were performed to derive SW weights. MM patients and patient organisations provided extensive feedback during survey development. Results 393 MM patients across 21 countries completed the survey (Myears since diagnosis=6; Mprevious therapies=3). Significant differences (p<.01) between participants’ attribute weights were revealed depending on participants’ prior therapy experience, and their experience with side-effects and symptoms. Multivariate analyses showed that participants across the three MM patient classes identified via the latent class model differed regarding their past number of therapies (F=4.772, p=.009). Patients with the most treatments (class 1) and those with the least treatments (class 3) attached more value to life expectancy versus quality of life-related attributes such as pain, mobility and thinking problems. Conversely, patients with intermediary treatment experience (class 2) attached more value to quality of life-related attributes versus life expectancy. Participants highlighted the difficulty of trading-off between life expectancy and quality of life and between physical and mental health. Participants expressed a need for greater psychological support to cope with their symptoms, treatment side-effects, and uncertainties. With respect to patients’ preferences for the DCE or SW questions, 42% had no preference, 32% preferred DCE, and 25% preferred SW. Conclusions Quality of life-related attributes affecting MM patients’ physical, mental and psychological health such as pain, mobility and thinking problems were considered very important to MM patients, next to life expectancy. This underscores a need to include such attributes in decision-making by healthcare stakeholders involved in MM drug development, evidence generation, evaluation, and clinical practice. This study highlights DCE as the preferred methodology for understanding relative attribute weights from a patient’s perspective.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- What matters most to patients with multiple myeloma? A Pan-European patient preference study
- Date Crossref
- 29/11/2022
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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KU Leuven pays non établi dans la noticeUniversité ou école supérieure
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European Federation of Allergy and Airways Diseases Patients Associations pays non établi dans la noticeOrganisation à but non lucratif
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Oslo University Hospital Department of Haematology pays non établi dans la noticeÉtablissement de santé
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University of Oslo K. G. Jebsen Center for B cell Malignancies pays non établi dans la noticeUniversité ou école supérieure
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Hospital de Sant Joan Despí Moisès Broggi pays non établi dans la noticeÉtablissement de santé
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Université Libre de Bruxelles Institute for Interdisciplinary Innovation in Healthcare (I3h) pays non établi dans la noticeUniversité ou école supérieure
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Department of Pharmaceutical and Pharmacological Sciences pays non établi dans la noticeInstitution
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Myeloma Patients Europe pays non établi dans la noticeInstitution
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CMP Flanders pays non établi dans la noticeInstitution
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School Psychology and Development in Context pays non établi dans la noticeInstitution
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University Hospital Leuven Department of Oncology pays non établi dans la noticeUniversité ou école supérieure
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H. Moises Broggi/ICO-Hospitalet Department of Haematology pays non établi dans la noticeÉtablissement de santé
KU Leuven, European Federation of Allergy and Airways Diseases Patients Associations et Department of Haematology — Oslo University Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.