A Survey of 30 years of Pediatric Clinical Trial Radiotherapy Dose Constraints
Rattachement africain : us, nl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Radiation therapy normal tissue dose constraints are critical when treating pediatric patients. However, there is limited evidence supporting proposed constraints which has led to variations in constraints over the years. In this study we identify these variations in dose constraints within pediatric trials both in the United States (US) and in Europe used in the past 30 years. Procedure: All pediatric trials from the Children’s Oncology Group website were queried from inception until January 2022 and a sampling of European studies was included. Dose constraints were identified and built into an organ-based interactive web application with filters to display data by organs-at-risk (OARs), protocol, start date, dose, volume, and fractionation scheme. Dose constraints were evaluated for consistency over time and compared between pediatric US trials and European trials Results: One hundred and five closed trials were included—93 US trials and 12 European trials. Thirty-eight separate OARs were found with high dose constraint variability. Across all trials, nine organs had greater than 10 different constraints (median 16, range 11-26), including serial organs. When comparing US versus European dose tolerances, US constraints were higher for seven OARs, lower for one, and identical for five. No OARs had constraints change systematically over the last 30 years. Conclusion: Review of pediatric dose-volume constraints in clinical trials showed substantial variability for all OARs. Continued efforts focused on standardization of OAR dose constraints and risk profiles are essential to increase consistency of protocol outcomes and ultimately to reduce radiation toxicities in the pediatric population.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Survey of 30 years of Pediatric Clinical Trial Radiotherapy Dose Constraints
- Date Crossref
- 11/11/2022
- Éditeur
- Wiley
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Southern California pays non établi dans la noticeUniversité ou école supérieure
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Los Angeles Medical Center pays non établi dans la noticeÉtablissement de santé
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Children's Hospital of Los Angeles pays non établi dans la noticeOrganisme public
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Ochsner Medical Center pays non établi dans la noticeÉtablissement de santé
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Princess Máxima Center pays non établi dans la noticeÉtablissement de santé
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University of Rochester pays non établi dans la noticeUniversité ou école supérieure
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Amsterdam University Medical Centers pays non établi dans la noticeÉtablissement de santé
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Children's Hospital Los Angeles pays non établi dans la noticeÉtablissement de santé
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Ochsner Lafayette General pays non établi dans la noticeInstitution
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Prinses Maxima Centrum voor Kinderoncologie pays non établi dans la noticeInstitution
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Amsterdam Universitair Medische Centra pays non établi dans la noticeInstitution
University of Southern California, Los Angeles Medical Center et Children's Hospital of Los Angeles, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.