Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study
Rattachement africain : ca, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Accurate and timely testing for SARS-CoV-2 in the pediatric population is crucial to control the COVID-19 pandemic; saliva testing has been proposed as a less invasive alternative to nasopharyngeal swabs. We sought to compare the detection of SARS-CoV-2 using saliva versus nasopharyngeal swab in the pediatric population, and to determine the optimum time of testing for SARS-CoV-2 using saliva. METHODS: We conducted a longitudinal diagnostic study in Ottawa, Canada, from Jan. 19 to Mar. 26, 2021. Children aged 3-17 years were eligible if they exhibited symptoms of COVID-19, had been identified as a high-risk or close contact to someone confirmed positive for SARS-CoV-2 or had travelled outside Canada in the previous 14 days. Participants provided both nasopharyngeal swab and saliva samples. Saliva was collected using a self-collection kit (DNA Genotek, OM-505) or a sponge-based kit (DNA Genotek, ORE-100) if they could not provide a saliva sample into a tube. RESULTS: Among 1580 paired nasopharyngeal and saliva tests, 60 paired samples were positive for SARS-CoV-2. Forty-four (73.3%) were concordant-positive results and 16 (26.6%) were discordant, among which 8 were positive only on nasopharyngeal swab and 8 were positive only on saliva testing. The sensitivity of saliva was 84.6% (95% confidence interval 71.9%-93.1%). INTERPRETATION: Salivary testing for SARS-CoV-2 in the pediatric population is less invasive and shows similar detection of SARS-CoV-2 to nasopharyngeal swabs. It may therefore provide a feasible alternative for diagnosis of SARS-CoV-2 infection in children.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study
- Date Crossref
- 01/10/2022
- Éditeur
- CMA Impact Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dalhousie University Division of Otolaryngology — Head and Neck Surgery (Corsten) pays non établi dans la noticeUniversité ou école supérieure
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University of Ottawa Department of Otolaryngology - Head and Neck Surgery (Hua pays non établi dans la noticeUniversité ou école supérieure
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Public Health Agency of Canada pays non établi dans la noticeOrganisme public
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Children's Hospital of Eastern Ontario Department of Pediatrics and Emergency Medicine (Bhatt pays non établi dans la noticeÉtablissement de santé
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Ottawa Hospital Chronic Disease Program (Angel) pays non établi dans la noticeÉtablissement de santé
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Children's Hospital Research Institute of Manitoba pays non établi dans la noticeÉtablissement de santé
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Ottawa University pays non établi dans la noticeUniversité ou école supérieure
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University of Manitoba Department of Pediatrics and Child Health (Poliquin) pays non établi dans la noticeUniversité ou école supérieure
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National Microbiology Laboratory (Bello pays non établi dans la noticeStructure de recherche
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National Microbiology Laboratory (Champredon) pays non établi dans la noticeStructure de recherche
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National Microbiology Laboratory (Milwid pays non établi dans la noticeStructure de recherche
Division of Otolaryngology — Head and Neck Surgery (Corsten) — Dalhousie University, Department of Otolaryngology - Head and Neck Surgery (Hua — University of Ottawa et Public Health Agency of Canada, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.