Association of IGF1 polymorphisms with exotropia in a Pakistani cohort.

Le résumé fourni par la source

Purpose: with STBMS in Pakistan. Methods: mRNA expression was measured by quantitative PCR; the Mann-Whitney U test was applied, and fold change was calculated. Logistic regression analysis was applied to determine the association of RNA expression and fold change with genotype. Results: mRNA expression in the extraocular muscles between the STBMS cases and the controls was observed. Conclusions: polymorphisms rs5742632 (A>G) and rs6214 (C>T) are plausible risk factors for the development of exotropia. However, the physiologic mechanism requires further evaluation.

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