Physisorption of DNA bases on finite-size nanoribbons from graphene,\n phosphorene, and silicene: Insights from density functional theory

Le résumé fourni par la source

The ability to detect and discriminate DNA bases by reading it directly using\nsimple and cost-effective methods is an important problem whose solution can\nproduce significant value for areas such as cancer and human genetic disorders.\nTwo-dimensional (2D) materials have emerged as revolutionary materials for\nelectronic DNA sequencing with strong potentials for fast, single-nucleotide\ndirect-read DNA sequencing with a minimum amount of consumables. Among 2D\nmaterials, graphene is the most explored for DNA sequencing. This is due to its\ncommercial availability. The major hindrance of graphene is its hydrophobicity,\nwhich causes DNA bases to stick to its surface, slowing down translocation\nspeed, and making single-base discrimination difficult as multiple bases\ninteract with graphene at any given time. It is therefore essential that other\nelemental 2D materials beyond graphene be investigated. Using density\nfunctional theory (DFT), we studied the electronic interaction of DNA bases\nphysisorped onto the surface of nanoribbons from graphene, phosphorene, and\nsilicene. By comparing the change in energy band gap, binding energy and\ndensity of states (DOS), we observe that phosphorene performs better than\ngraphene and silicene for DNA sequencing using the physisorption modality.\n

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.