Accès ouvert déclaré2022article

A Novel Ex Vivo Drug Assay for Assessing the Transmission-Blocking Activity of Compounds on Field-Isolated Plasmodium falciparum Gametocytes

Dinkorma Ouologuem, Laurent Dembélé, Antoine Dara, Aminatou Koné, Nouhoum Diallo, Cheick P. O. Sangare, Fatoumata I. Ballo, François Dao, Siaka Goïta, Aboubecrin Haidara, Aliou Traoré, Amadou Niangaly, Souleymane Dama, Sékou Sissoko, Fanta Sogore, Jacob N. Dara, Yacouba N. Barre, Amadou Daou, Fatoumata Cissé, Ousmaila Diakité, Diagassan Doumbia, Sekou Koumaré, Bakary Fofana, Fatalmoudou Tandina, Daman Sylla, Adama Sacko, Mamadou Coulibaly, Mamadou Teketé, Amed Ouattara, Abdoulaye Djimdé

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2Institutions associées

2Pays d’affiliation

Résumé fourni par la source

The discovery and development of transmission-blocking therapies challenge malaria elimination and necessitate standard and reproducible bioassays to measure the blocking properties of antimalarial drugs and candidate compounds. Most of the current bioassays evaluating the transmission-blocking activity of compounds rely on laboratory-adapted Plasmodium strains.

Institutions

Malaria Research and Training Center University of Maryland, Baltimore

Sujets associés

Malaria Research and ControlMosquito-borne diseases and controlHIV Research and Treatment

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