Is a Preservation Solution for Living Donor Liver Transplantation Needed? Adding a New Chapter in LDLT!
Rattachement africain : pk, in, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background. Preservation solutions are required for organ viability in deceased donor liver transplantation (LT). However, their role in live donor LT (LDLT) has not been standardized. Methods. Eighty adult recipients who underwent right lobe LDLT at the Department of Liver Transplantation Surgery, Gambat, Pakistan, were studied. Based on shorter cold ischemia time and no back table reconstruction work, recipients were assigned to receive “no preservation solution” (cases/non–histidine-tryptophan-ketoglutarate group; n = 40) or “HTK group” (controls; n = 40). Early allograft dysfunction (bilirubin, transaminases, and international normalized ratio), postoperative complications (biliary and vascular), hospital stay, and 1-y survival were reported. The direct cost was also reported. Results. Demographics and clinical characteristics were comparable in the 2 groups. Comparing cases versus controls, mean bilirubin, alanine aminotransferase, aspartate aminotransferase, and international normalized ratio on postoperative day 7 were similar in the 2 groups. Five (12.5%) cases and 4 (10%) controls developed early allograft dysfunction (P = 0.72). Post-LT complications (biliary leak 2.5% in cases versus 0 in control), strictures (15% in cases versus 17.5% in controls), hepatic artery thrombosis (2.5% versus 00%)‚ and portal vein thrombosis (0 versus 2.5%) were comparable. Mean hospital stay (10.80 + 2.36 and 11.78 + 2.91 d) and 30 d mortality (2.5% versus 5%) were also comparable. Finally, 1-y survival based on Kaplan-Meier analysis was comparable in both groups (ie, 92.5%; non-HTK group versus 90%; HTK group) (P = 0.71). The direct cost of using a non-HTK–based approach was less than the HTK solution. Conclusion. In a selected cohort of right lobe LDLT recipients, preservation solutions can be avoided safely with comparable outcomes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Is a Preservation Solution for Living Donor Liver Transplantation Needed? Adding a New Chapter in LDLT!
- Date Crossref
- 07/10/2022
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Pakistan Institute of Medical Sciences pays non établi dans la noticeÉtablissement de santé
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Shifa International Hospital pays non établi dans la noticeÉtablissement de santé
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Max Super Speciality Hospital pays non établi dans la noticeÉtablissement de santé
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The Ohio State University Wexner Medical Center Hepatology‚ and Nutrition pays non établi dans la noticeÉtablissement de santé
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Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences pays non établi dans la noticeStructure de recherche
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Max Speciality Hospital New Delhi pays non établi dans la noticeÉtablissement de santé
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Division of Comprehensive Transplant Center‚ The Ohio State University pays non établi dans la noticeUniversité ou école supérieure
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Division of Comprehensive Transplant Center' The Ohio State University pays non établi dans la noticeUniversité ou école supérieure
Pakistan Institute of Medical Sciences, Shifa International Hospital et Max Super Speciality Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.